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UW School of Dentistry

team: OHS Faculty

Robert A. Cornell

Research Interests

Genetic underpinnings of orofacial cleft; Transcriptional regulatory networks governing cellular differentiation of superficial epithelia and melanocytes; Cell fate determination.

Publications

Fritzie Arce-McShane

Background

Dr. Arce-McShane is an Assistant Professor in the Department of Oral Health Sciences. She received her Bachelor of Science in Physical Therapy from the University of the Philippines, Master of Arts in Motor Learning from Columbia University in New York, and PhD in Neuroscience from the Hebrew University of Jerusalem in Israel. She did her postdoctoral work at the University of Chicago and was a Research Assistant Professor prior to joining the School of Dentistry in November 2021.

Research Interests

Dr. Arce-McShane is a neuroscientist and her research focuses on the principles of cortical and biomechanical control of oral sensorimotor behavior (such as feeding, breathing and speech), and how these are affected by learning, aging, and disease. Her previous background as a physical therapist with strong concentrations in movement science, neurological and cognitive rehabilitation has given her a keen awareness of patients’ problems and needs. Her basic science research draws from her clinical experience and is aimed  towards innovative research that directly impacts the evaluation and treatment of neurodegenerative diseases, sensorimotor disorders, restoration of sensory feedback in brain-machine interfaces, and age-related dementias.

Her lab uses a multidisciplinary approach to understand the interplay between sensation and movement using converging evidence from psychophysics, biomechanics, neurophysiology, and computational modeling. Her methods include recording neural activity from chronically-implanted microelectrode arrays in multiple regions of the cerebral cortex simultaneous with recording the movements of the tongue and the mandible using high-resolution biplanar radiography and applying computational models to understand the principles of sensorimotor control.

Research Lab website

Selected Publications

  1. Arce-McShane FI (2021) The association between age-related changes in oral neuromechanics and Alzheimer’s disease. Adv Geriatr Med Res 2021;3(2):e210011. https://doi.org/10.20900/agmr20210011
  2. Laurence-Chasen J, Manafzadeh AR, Hatsopoulos NG, Ross CF, Arce-McShane FI (2020) Integrating XMALab and DeepLabCut for high-throughput XROMM. Journal of Experimental Biology 2020 223: jeb226720 doi: 10.1242/jeb.226720
  3. Arce-McShane FI, Sessle BJ, Ram Y, Takahashi K, Balcer C, Ross CF, Hatsopoulos NG (2020) Multiple regions of primate orofacial sensorimotor cortex encode bite force and gape. bioRxiv doi:https://doi.org/10.1101/2020.08.16.252817
  4. Arce-McShane FI, Sessle BJ, Ross CF, Hatsopoulos NG (2018) Primary sensorimotor cortex exhibits complex dependencies of spike-field coherence on neuronal firing rates, field power, and behavior. Journal of Neurophysiology 120 (1):226-238
  5. Arce-McShane FI, Takahashi K, Ross CF, Sessle BJ, Hatsopoulos NG (2016) Primary motor and sensory cortical areas communicate via spatiotemporally coordinated networks at multiple frequencies. Proceedings of National Academy of Sciences 113(18):5083-5088
  6. Arce-McShane F, Hatsopoulos NG, Lee JC, Ross CF, Sessle BJ (2014) Modulation dynamics in the orofacial sensorimotor cortex during motor skill acquisition. Journal of Neuroscience 34(17):5985-5997
  7. Arce F, Ross CF, Lee JC, Sessle BJ, Hatsopoulos NG (2013) Directional information from neuronal ensembles in the primate orofacial sensorimotor cortex. Journal of Neurophysiology 110(6):1357-1369

Recent Conference Poster Presentations

  1. Sheridan L, Laurence-Chasen JD, Arce-McShane FI (2021). Sensory loss affects multi-region neural network dynamics in primate sensorimotor cortex. 2021 Society for Neuroscience Conference (accepted)
  2. Luckas J, Laurence-Chasen JD, Fereira III H, Arce-McShane FI (2021). Novel biomarkers in healthy aging: Tongue and jaw kinematics as a potential way to further explore Alzheimer’s-induced biological changes. 2021 Alzheimer’s Association International Conference
  3. Tang D, Simonoff A, Laurence-Chasen JD, Arce-McShane FI (2021) Decoding lingual-palatal contacts from population responses in primate orofacial sensorimotor cortex. Computational and Systems Neuroscience (Cosyne) 2021
  4. Tang D, Simonoff A, Laurence-Chasen JD, Sessle B, Ross C, Hatsopoulos NG, Arce-McShane FI (2021) Decoding lingual-palatal contacts from population responses in primate orofacial sensorimotor cortex. Society for Neuroscience Global Connectome
  5. Laurence-Chasen JD, Ross CF, Hatsopoulos NG, Arce-McShane F (2021) Decoding tongue position and shape from population responses in primate orofacial sensorimotor cortex. Society for Neuroscience Global Connectome
  6. Laurence-Chasen JD, Manafzadeh AR, Hatsopoulos NG, Ross CF, Arce-McShane F (2021) XROMM Tools for DeepLabCut: Bringing deep learning to XROMM marker tracking. Virtual Society for Integrative and Comparative Biology

Jonathan An

Background

Dr. An received his Bachelor of Science in Molecular, Cellular and Developmental Biology from the University of Washington. He completed a dual D.D.S (2015) and Ph.D (2019) from the University of Washington School of Dentistry. He is a UW Magnuson Scholar, ARCS Foundation Fellow, IADR/AADR Hatton Competition winner, and won the inaugural IADR Heraeus Award and ADA/Dentsply Sirona Research Award for Dual Degree Candidates.

Academic and Clinical Activities

Dr. An is currently an Assistant Professor of Oral Health Sciences and Faculty in the Healthy Aging and Longevity Institute. He also serves as the Assistant Graduate Program Director of Oral Health Sciences. Dr. An currently directs courses in the departments of Oral Health Sciences and the Department of Lab Medicine and Pathology.

Research Interests

Dr. An’s research interests lie at the intersection of Geroscience (aging biology) and Oral Biology. His primary research focuses on understand the basic biological mechanisms of aging in the context of oral health and disease.  His laboratory also evaluates and targets specific hallmarks of aging in the oral cavity to one day translate these discoveries to help extend the oral healthspan in humans.

Recent Publications

  1. Buranaphatthana, W.; Yavirach, A.;  Leaf, E. M.;  Scatena, M.;  Zhang, H.;  An, J. Y.; Giachelli, C. M., Engineered osteoclasts resorb necrotic alveolar bone in anti-RANKL antibody-treated mice. Bone 2021, 153, 116144.
  2. An JY, Kerns KA, Ouellette A, Robinson L, Morris HD, Kaczorowski C, Park SI, Mekvanich T, Kang A, McLean JS, Cox TC, Kaeberlein M. Rapamycin rejuvenates oral health in aging mice. Elife. 2020 Apr 28;9. PMID: 32342860; PMCID: PMC7220376.
  3. An JY, Darveau R, Kaeberlein M. Oral health in geroscience: animal models and the aging oral cavity. Geroscience. 2018 Feb;40(1):1-10. PMID: 29282653; PMCID: PMC5832657.
  4. An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M. Rapamycin treatment attenuates age-associated periodontitis in mice. Geroscience. 2017 Aug;39(4):457-463. PMID: 28889220; PMCID: PMC5636779.
  5. Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M. Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Front Genet. 2017;8:113 PMID: 28919908; PMCID: PMC5585733.
  6. Chung WO, Wataha JC, Hobbs DT, An J, Wong JJ, Park CH, Dogan S, Elvington MC, Rutherford RB. Peroxotitanate- and monosodium metal-titanate compounds as inhibitors of bacterial growth. J Biomed Mater Res A. 2011 Jun 1;97(3):348-54. PubMed PMID: 21472975.
  7. Rohani MG, DiJulio DH, An JY, Hacker BM, Dale BA, Chung WO. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes. BMC Immunol. 2010 Oct 28;11:53. PMID: 21029417; PMCID: PMC2988058.
  8. Chung WO, An JY, Yin L, Hacker BM, Rohani MG, Dommisch H, DiJulio DH. Interplay of protease-activated receptors and NOD pattern recognition receptors in epithelial innate immune responses to bacteria. Immunol Lett. 2010 Jul 8;131(2):113-9. PubMed PMID: 20219537; PubMed Central PMCID: PMC2885501.
  9. Yin L, Swanson B, An J, Hacker BM, Silverman GA, Dale BA, Chung WO. Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2. J Oral Microbiol. 2010 May 4;2.PMID: 21523231; PMCID: PMC3084571.

Cameron L. Randall

Randall

I am an Acting Assistant Professor in the Department of Oral Health Sciences at the University of Washington School of Dentistry. My program of research applies behavioral science, especially health psychology, to dentistry and dental public health. The overall goals of this work are to improve dental care delivery and oral health outcomes, with a major aim to reduce health disparities.

I have specific research interests in: (1) psychological processes involved in, and social/behavioral interventions for, dental/orofacial pain, dental treatment-seeking behavior, and oral health behavior; (2) the etiology, prevention, and amelioration of dental treatment avoidance, particularly as a function of dental care-related fear/anxiety; and (3) the dissemination of knowledge on these topics to healthcare professionals, and the implementation of evidence-based practice in the oral health arena. As a clinical psychologist, I treat patients in the oral medicine clinic at the University of Washington School of Dentistry.

I also engage in teaching—primarily for dental and medical students/residents—on topics such as behavioral science, clinical health psychology, health behavior change, healthcare-related fear/anxiety, pain management, pediatric behavior guidance, integrated care, Motivational Interviewing, interprofessional and patient-provider communication, and cultural humility.

My research applies social and behavioral science to dentistry. To guide my work, I draw on training in experimental psychopathology, behavioral genetics, clinical health psychology, dissemination and implementation science, public health, and translational science. Three specific areas of scientific inquiry currently characterize my multilevel, transdisciplinary program of research.

  1. Randall, C. L. (2018). On motivational interviewing for oral health promotion: State of the field and future directions. JDR Clinical and Translational Research, 3(4), 376-377. [PDF]
  2. Ford, C., Manegold, E., Randall, C. L., Aballay, A., & Duncan, C. L. (in press). Assessing the feasibility of implementing low-cost virtual reality therapy during routine burn care. Burns, 44(4), 886-895. [PDF]
  3. McNeil, D. W., Kennedy, S. G., Randall, C. L., Addicks, S. H., Wright, C. D., Hursey, K. G., & Vaglienti, R. (2018). The Fear of Pain Questionnaire-9: Brief assessment of fear of pain. European Journal of Pain, 22(1), 39-48. [PDF]
  4. McNeil, D. W., Addicks, S. H., & Randall, C. L. (2017). Motivational interviewing for health behavior change. Oxford Handbooks Online. doi: 10.1093/oxfordhb/9780199935291.013.21 [PDF]
  5. Mittinty, M. M., Brennan, D. S., Randall, C. L., McNeil, D. W., Mittinty, M. N., & Jamieson, L. (2017). Influence of fear of pain and coping strategies on health-related quality of life and patient-anticipated outcomes in patients with chronic pain: Cross-sectional study protocol. JMIR Research Protocols, 6(9), e176. [PDF]
  6. Randall, C. L., & McNeil, D. W. (2017). Motivational interviewing as an adjunct to cognitive behavior therapy for anxiety disorders: A critical review of the literature. Cognitive and Behavioral Practice, 24(3), 296-31. [PDF]
  7. Addicks, S. H., McNeil, D. W., Randall, C. L., Goddard, A., Romito, L., Sirbu, C., Kaushal, G., Metzger, A., & Weaver, B. D. (2017). Dental care-related fear and anxiety: Distress tolerance as a possible mechanism. JDR Clinical & Translational Research, 2(3), 304-311. [PDF]
  8. Randall, C. L., Wright, C. D., Chernus, J., McNeil, D. W., Feingold, E., Crout, R. J., Neiswanger, K., Weyant, R. J., Shafer, J.R., & Marazita, M. L. A preliminary genome-wide association study of pain-related fear: Implications for orofacial pain. Pain Research and Management, 2017, 7375468. [PDF]
  9. Randall, C. L., Shaffer, J. R., McNeil, D. W., Crout, R. J., Weyant, R. J., & Marazita, M. L. (2017). Toward a genetic understanding of dental fear: Evidence of heritability. Community Dentistry and Oral Epidemiology, 45(1), 66-73. [PDF]
  10. Randall, C. L., McNeil, D. W., Shaffer, J. R., Crout, R. J., Weyant, R. J., & Marazita, M. L. (2016). Fear of pain mediates the association between MC1R genotype and dental fear. Journal of Dental Research, 95(10), 1132-1137. [PDF]
  11. McNeil, D. W., Hayes, S. E., Randall, C. L., Polk, D. E., Neiswanger, K., Shaffer, J. R., Weyant, R. J., Foxman, B., Kao, E., Crout, R. J., Chapman, S., Brown, L. J., Maurer, J. L., & Marazita, M. L. (2016). Depression and a Rural Environment are Associated with Poor Oral Health among Pregnant Women in Northern Appalachia. Behavior Modification, 40(2), 325-340. [PDF]
  12. Bamonti, P. M., Keelan, C. M., Larson, N., Mentrikoski, J. M., Randall, C. L., Sly, S. K., Travers, R. M., & McNeil, D. W. (2014). Promoting ethical behavior by cultivating a culture of self-care during graduate training: A call to action. Training and Education in Professional Psychology, 8(4), 253-260. [PDF]
  13. Randall, C. L., Shulman, G. P., & McNeil, D. W. (2014). Gagging during dental treatment: Associations with dental care-related fear, fear of pain, and beliefs about treatment. Journal of the American Dental Association, 145, 452-458. [PDF]
  14. Randall, C. L., McNeil, D. W., Crout, R. J., Weyant, R. J., & Marazita, M. L. (2013). Collecting psychosocial self-report data in oral-health research: Impact of literacy level and computerized administration. Social Science and Dentistry, 2(2), 80-87. [PDF]

C. Michele Lloid

Lloid
Ms. Lloid is a recognized clinical expert on the oral tissue manifestations of bone marrow transplantation and graft versus host disease and has been involved in treating bone marrow transplant recipients. She is one of the key clinical personnel in Oral Medicine studies dealing with the management of transplant related oral mucositis, changes in oral microflora, oral tissue pathologies and other effects of transplant-related procedures. Her roles include recruiting subjects, collaborating in designing treatment and data collection protocols, organizing the collected data, ensuring study procedures were followed, collaborating on data analysis and interpretation, and collaborating on writing the resulting manuscripts.

  1. Lloid, Michele E. Oral Examination. In ONS Blood and Bone Marrow Stem Cell Transplant Special Interest Group Newsletter. Volume 18, Issue 1 Feb. 2007
  2. Schubert, MM, Eduardo, FP, Guthrie, K, Franquine, JC, Bensadoun, RJ, Lloid, ME, Eduardo, CP, Niccoli-Filho, W, Marques, MM, Migliorati, CA, Hamdi, MA. Phase III randomized double-blind placebo controlled clinical trials to determine the efficacy of low energy laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation. Support Care Cancer. 15:1145-1147, 2007.
  3. Nash, RA, Johnston, L, Parker, P, McCune, JS, Storer, B, Slattery, JT, Furlong, T, Anasetti, C, Appelbaum, FR, Lloid, ME, Deeg, HF, Kiem, H-P, Martin, PJ, Schubert, MM, Witherspoon, RP, Forman, SJ, Blume, KJ, Storb, R. A Phase 1-2 Study of Mycophenolate Mofetil in Combination with Cyclosporine for Prophylaxis of Acute Graft-versus-Host Disease after Myeloablative Conditioning and Allogeneic Hematopoietic Cell Transplantation. Boil Blood Marrow Transplant. 11:495-505, 2005.
  4. Robien, K, Schubert, MM, Bruemmer, B, Lloid, ME, Potter, JD, Ulrich, CM. Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia. J Clin Oncol, 22(7):1268-75, 2004.

Marilynn Rothen

Research Interests

Current research interests are primarily in the area of dental caries management and caries risk assessment, in addition to a long standing interest in the treatment of patients with dental fear and related behavior modification.

Publications

  1. Cuhna-Cruz, J., Wataha, J.C., Heaton, L.J., Rothen, M., Sobieraj, M., Scott, J., and Berg, J.  The prevalence of dentin hypersensitivity in general dental practices in the northwest United States. J Am Dent Assoc 2013; 144:288-96.
  2. Cuhna-Cruz, J., Scott, J., Rothen, M., Mancl, L., Lawton, T., Brossel, K., and Berg, J. Salivary Characteristics and Dental Caries: Evidence from General Dental Practices. J Am Dent Assoc 2013; 144:e31-40.
  3. Rothen, M., Cunha-Cruz, J., Mancl, L., Leroux, B., Latzke Davis, B., Coyne, J., Gillette, J., Berg, J. Inter-examiner Reliability of Salivary Diagnostic Tests in a Practice-based Research Network. J Dent Hyg 2011; 85:143-50.
  4. Persson, G.R., Hitti, J., Verhelst, R., Vaneechoutte, M., Persson, R.E., Hirschi, R., Weibel, M., Rothen, M., Temmerman, M., Paul, K., Eschenbach, D. The vaginal microflora in relation to gingivitis. BMC Infectious Diseases 2009, 9:6.
  5. Ly, K.A., Riedy, C.A., Milgrom, P., Rothen, M., Roberts, M.C., Zhou, L. Xylitol Gummy Bear Snacks: A School-based Randomized Clinical Trial. BMC Oral Health 2008 Jul 25;8:20.
  6. Riedy, C.A., Milgrom, P., Ly, K.A., Rothen, M., Mueller, G., Hagstrom, M.K., Tolentino, E., Zhou, L., Roberts, M.C. A Surrogate Method for Comparison Analysis of Salivary Concentrations of Xylitol-Containing Products. BMC Oral Health 2008, 8:5.
  7. Ly, K.A., Milgrom, P., Roberts, M.C., Yamaguchi, D.K., Rothen, M., Mueller, G. Linear Response of Mutans Streptococci to Increasing Frequency of Xylitol Chewing Gum Use: A Randomized Controlled Trial.  BMC Oral Health 2006 Mar 24; 6:6.
  8. Milgrom, P., Ly, K.A., Roberts, M.C., Rothen, M., Mueller, G., Yamaguchi, D.K.  Mutans Streptococci Dose Response to Xylitol Chewing Gum.  J Dent Res 2006; 85: 177-181.

Tracy Popowics

Popowics
Dr. Popowics’ research investigates the biomechanics of dental and craniofacial tissues across multiple scales and tissue types. This work examines how biomechanical processes that occur at the macroscale, such as tooth loading during mastication, influence processes that occur at the nanoscale including cellular functions, and vice versa. Her pursuit of an understanding of load transmission within orofacial tissues on these two scales is critical to understanding the etiology of pathological conditions.

  1. DENTFN 523: Oral Histology and Embryology 1
  2. DENTFN 533: Oral Histology and Embryology 2
  1. Houg, K.P., Armijo, L., Major, P., Popowics, T., Dennison, C. and Romanyk,D. Experimental repeatability, sensitivity, and reproducibility of strain and force measurements during ex vivo tooth loading. J. Mech. Behav. Biomed. Mater. 2021; 120 DOI: 10.1016/j.jmbbm.2021.104562.
  2. Al-Rekabi, Z., Fura, A.M., Juhlin, I., Yassin, A., Popowics, T.E. and Sniadecki, N.J. Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells. Cell Adhes. Migr. 2019; 13(1): 138-150, 2019.
  3. Hudson D.M., Garibov, M., Dixon, D.R., Popowics T.E. and Eyre, D.R. Distinct post- translational features of type I collagen are conserved in mouse and human periodontal ligament. Periodont. Res. 2017; 52:1042– 1049.
  4. Popowics, T.E., Yeh, K.D., Rafferty, K., and Herring, S.W.: Functional cues in the development of osseous tooth support in the pig, Sus scrofa. Biomech. 42(12): 1961-6, 2009.
  5. Popowics, T.E., and Herring, S.W.: Load transmission in the nasofrontal suture of the pig, Sus scrofa. J. Biomech. 40(4): 837-44, 2007.

Lloyd Mancl

Mancl
His research interests are in statistical methods for dental research, with an emphasis on longitudinal and correlated data and applied research on caries, temporomandibular disorders, and periodontal disease. For over 15 years he has served as a biostatistician on numerous and varied research projects, including basic science and experimental studies, large observational and longitudinal studies, single and multi-center randomized clinical trials, and practice based research. Currently, he is the director of the Statistics & Data Coordinating Center for the Northwest Center to Reduced Oral Health Disparities, anda co-investigator in the Data & Coordinating Center for Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NW-PRECEDENT).

  1. Richman JA, Huebner CE, Leggott PJ, Mouradian WE, Mancl LA. “Beyond word recognition: understanding pediatric oral health literacy.” Pediatric Dentistry, 2011; 33(5): 420-425. PMCID: In process
  2. Chen IC, Brudvik JS, Mancl LA, Rubenstein JE, Chitswe K, Raigrodski AJ. “Freedom of rotation of selected overdenture attachments: An in vitro study.”  Journal of Prosthetic Dentistry, 2011; 106(2): 78-86.
  3. Turner JA, Mancl L, Huggins HK, Sherman JJ, Lentz G, Leresche L. “Targeting temporomandibular disorder pain treatment to hormonal fluctuations: A randomized clinical trial.” Pain, 2011; 152(9): 2074-2084. PMCID: PMC3157596.
  4. Janssens KAM, Rosmalen JGM, Ormel J, Verhulst FC, Hunfeld JAM, Mancl LA, Oldehinkel AJ, LeResche L. “Pubertal status predicts back pain, overtiredness, and dizziness in American and Dutch adolescents.” Pediatrics, 2011; 128: 553-559. PMCID: PMC3164091
  5. Rothen M, Cunha-Cruz J, Mancl L, Leroux B, Davis BL, Coyne J, Gillette J, Berg J. “Inter-examiner reliability of salivary diagnostic tests in a practice-based research network.” The Journal of Dental Hygiene, 2011; 85(2): 143-150. PMCID: In process
  6. Castillo JL, Rivera S, Aparicio T, Lazo R, Aw TC, Mancl L, Milgrom P. “The short-term effects of diammine silver on tooth sensitivity: a randomized controlled trial.” Journal of Dental Research, 2011; 90(2): 203-208.
  7. Milgrom P, Ly KA, Tut OK, Mancl L, Roberts M, Briand K, Gancio MJ. “Xylitol pediatric topical oral syrup to prevent dental caries: a double-blind randomized clinical trial of efficacy.”  Arch Pediatr Adolesc Med, 2009;163(7):601-7. (IADR Aubrey Sheiham Award for Distinguished Research in Dental Public Health Sciences, 2010). PMCID: PMC2722805
  8. LeResche, L., Mancl, L.A., Drangsholt, M.T., Huang, G. “Predictors of onset of facial pain and temporomandibular disorders in early adolescents.” Pain, 129, 269-278, 2007.  PMCID: PMC1979093  (IADR Aubrey Sheiham Award for Distinguished Research in Dental Public Health Sciences, 2008)
  9. DeRouen T.A., Hujoel P., Leroux B., Mancl L., Sherman J., Hilton T., Berg J., Ferracance J. for the Northwest Practice-based Research Collaborative in Evidence-based Dentistry (PRECEDENT). “Preparing practicing dentists to engage in practice-based research.” Journal of the American Dental Association, 139, 339-345, 2008.
  10. Leroux, B.G., Mancl, L.A., DeRouen, T.A. “Group sequential testing in dental clinical trials with longitudinal data on multiple outcome variables.” Statistical Methods in Medical Research, 14, 591-602 2005. Mancl L.A., Hujoel P.P., DeRouen T.A. “Efficiency issues among statistical methods for demonstrating efficacy of caries prevention – site versus subject.” Journal of Dental Research, 83 (Special Issue C), C95-C98, 2004.
  11. Dworkin, S.F., Huggins, K.H., Wilson, L., Mancl, L., Turner, J., Massoth, D., LeResche, L, Truelove, E. “A randomized clinical trial using research diagnostic criteria for temporomandibular disorders – Axis II to target clinic cases for a tailored self-care TMD treatment program.” Journal of Orofacial Pain, 16, 48-63. (Giddon Award for Distinguished Research in the Behavioral Sciences. Awarded by the Behavioral Sciences and Health Services Research Group of the International Association of Dental Research, 2003.)
  12. Mancl, L.A., DeRouen, T.A. “A covariance estimator for GEE with improved small sample properties.”  Biometrics, 57, 126-134, 2001.
  13. Mancl, L.A., Leroux, B.G., DeRouen, T.A. “Between-subject and within-subject statistical information in dental research.” Journal of Dental Research, 79, 1778-1781, 2000.
  14. Milgrom, P., Mancl, L., King, B., Weinstein, P., Wells, N., Jeffcott, E. “An explanatory model of the dental care utilization of low income children.” Medical Care, 36, 554-566 1998. (Giddon Award for Distinguished Research in the Behavioral Sciences. Awarded by the Behavioral Sciences and Health Services Research Group of the International Association of Dental Research, 1999.)
  15. Mancl, L.A., Leroux, B.G. “Efficiency of regression estimates for clustered data.” Biometrics, 52,500-511, 1996.

Brian Leroux

Leroux
Dr. Brian Leroux is a Professor in the Department of Oral Health Sciences with a joint appointment in the Department of Biostatistics. He received his PhD in Statistics from The University of British Columbia in 1989 and has been at the University of Washington since 1991. He is currently the director of the Data Coordinating Center for Northwest PRECEDENT, a practice-based dental research network.

Dr. Leroux’s main research interest is in statistical methods for correlated data with applications to dental research and other fields. In addition to his work on Northwest PRECEDENT he collaborates with Seattle Children’s Hospital investigators on studies on craniofacial anomalies and is a Biostatistician and Associate Director of the data coordinating center for the Resuscitation Outcomes Consortium which conducts clinical trials in emergency medicine.
  1. Collett BR, Speltz ML, Cloonan YK, Leroux BG, Kelly JP, Werler MM: Neurodevelopmental outcomes in children with hemifacial microsomia. Arch Pediatr Adolesc Med 165(2):134-140, Feb, 2011.
  2. Rothen M, Cunha-Cruz J, Mancl L, Leroux B, Davis BL, Coyne J, Gillette J, Berg J: Inter-examiner reliability of salivary diagnostic tests in a practice-based network. J Dental Hygiene 85(2):143-150, Spring, 2011.
  3. Barasch A, Cunha-Cruz J, Curro FA, Hujoel P, Sung AH, Vena D, Voinea-Griffin AE, for the CONDOR Collaborative Group (Beadnell S, Craig RG, DeRouen T, Desaranayake A, Gilbert A, Gilbert GH, Goldberg K, Hauley R, Hashimoto M, Holmes J, Latzke B, Leroux B, Lindblad A, Richman J, Safford M, Ship J, Thompson VP, Williams OD, Yin W): Risk factors for osteonecrosis of the jaws: a dental practice-based research network case-control study. J Dent Res 90(4):439-444,  2011.
  4. Dufton LM, Speltz ML, Kelly JP, Leroux B, Collett BR, Werler MM: Psychosocial outcomes in children with hemifacial microsomia. Journal of Pediatric Psychology 36(7):794-805, Aug, 2011.
  5. Stiell IG, Nichol G, Leroux BG, Rea TD, Ornato JP, Powell J, Christenson J, Callaway CW, Kudenchuk PJ, Aufderheide TP, Idris AH, Daya MR, Wang HE, Morrison LJ, Davis D, Andrusiek D, Stephens S, Cheskes S, Schmicker RH, Fowler R, Vaillancourt C, Hostler D, Zive D, Pirrallo RG, Vilke GM, Sopko G, Weisfeldt M, and the Resuscitation Outcomes Consortiurm (ROC) Investigators: Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest. New Eng J Med 365(9):787-797, Sept 1, 2011.
  6. Aufderheide TP, Nichol G, Rea TD, Brown SP, Leroux BG, Pepe PE, Kudenchuk PJ, Christenson J, Daya MR, Dorian P, Callaway CW, Idris AH, Andrusiek D, Nichol G, Stephens SW, Hostler D, Davis DP, Dunford JV, Pirrallo RG, Stiell IG, Clement CM, Craig A, Van Ottingham L, Schmidt TA, Wang HE, Weisfeldt ML, Ornato JP, Sopko G, and the Resuscitation Outcomes Consortiurm (ROC) Investigators: A trial of an impedance threshold device in out-of-hospital cardiac arrest. New Eng J Med 365(9):798-806, Sept 1, 2011.
  7. Huang Y, Leroux BG: Informative cluster sizes and weighted generalized estimating equations. Biometrics 67(3):843-851, Sep, 2011.
  8. Torres SR, Chen CSK, Leroux BG, Lee PP, Hollender LG, Schubert MM: Fractal dimension evaluation of cone beam computed tomography in patients with bisphosphonate-associated osteonecrosis. Dentomaxillofacial Radiology, 40(8):501-505, Dec, 2011.
  9. Flemmig TF, Arushanov D, Daubert D, Rothen M, Mueller G, Leroux BG: Randomized controlled trial assessing harm and efficacy of glycine powder air polishing in deep periodontal pockets. Journal of Periodontology, In Press, 2011.

Philippe P. Hujoel

Hujoel

Education:  The Free University of Brussels (dental degree), the University of Washington (specialty training in periodontics and a doctoral degree in epidemiology), and the University of Michigan (a master of science in biostatistics).

Service: Clinical practice limited to periodontics

  • Nutrition  with a focus on low carbohydrate diets
  • The harmful effects of diagnostic radiation
  • Evidence-Based Methodology and Applications
  • DPHS 535
  • DPHS 569
  1. Hujoel PP.  Vitamin D and Dental Caries:  Systematic Review and Meta-analysis. (2012) Nutrition Reviews. In press.
  2. Hujoel PP, Becker W, and  Becker B: Monitoring Failure Rates of Commercial Implant Brands; Substantial Equivalence in Question? (2012) Clinical Oral Implants Research.
  3. Hujoel P, Zina LG, Cunha-Cruz J, Lopez R. Historical perspectives on theories of periodontal disease etiology. Periodontol 2000. Feb 2012;58(1):153-160.
  4. Rethman MP, Beltran-Aguilar ED, Billings RJ, et al. Nonfluoride caries-preventive agents: executive summary of evidence-based clinical recommendations. J Am Dent Assoc. Sep 2011;142(9):1065-1071.
  5. Hujoel PP, Stott-Miller M. Retinal and gingival hemorrhaging and chronic hyperglycemia. Diabetes Care. Jan 2011;34(1):181-183.
  6. Hujoel P. Dietary carbohydrates and dental-systemic diseases. J Dent Res. Jun 2009;88(6):490-502.

Susan E. Coldwell

Coldwell
Susan Coldwell earned a BA in psychology from Duke University in 1989 and received an MA (1990) and PhD (1994) in psychology from the University of Pennsylvania and the Monell Chemical Senses Center.
Developmental and physiological influences on taste preference and perception. Psychophysical measurement of pain, anxiety, and taste.
  1. Desai H, Smutzer G, Coldwell SE, and Griffith JW.  Validation of Edible Taste Strips for Identifying PROP Taste Recognition Thresholds, The Laryngoscope, June, 121(6): 1177-1183, 2011.
  2. Coolidge T, Hillstead MB, Farjo N, Weinstein P, and Coldwell SE.  Additional Psychometric Data for the Spanish Modified Dental Anxiety Scale, and Psychometric Data for a Spanish Version of the Revised Dental Beliefs Survey, BioMed Central Oral Health, 10:12, 2010.
  3. Milgrom P, Weinstein P, and Coldwell SE.  “Malnutrition as an Etiological Factor in Dental Caries Disparity” pp. 381-395, in M. Wilson, ed. Food Constituents and Oral Health: Current Status and Future Prospects, Woodhead Publishing Ltd., 2009.
  4. Mobley C, Marshall TA, Milgrom P, and Coldwell SE.  The Contribution of Dietary Factors to Dental Caries and Disparities in Caries, Academic Pediatrics, 9(6), pp. 410-414, 2009.
  5. Coldwell SE, Oswald TK, and Reed DR.  A Marker of Growth Differs between Adolescents with High versus Low Sugar Preference, Physiology and Behavior, 96, 574-580, 2009.

Whasun “Sun” Oh Chung

Chung
  • Gingival innate immunity
  • Titanate-metal complexes as novel antimicrobials in dentistry (US Patent registered in 2013)
  • Epigenetic regulations in periodontal health and disease
  • Biological effects of dental metal alloys in oral tissues
  • Role of T2R38 taste receptor in oral immunity
  1. Yin, L., and W.O. Chung.  2011.  Epigenetic regulation of gingival innate immune responses to oral bacteria.  Mucosal Immunology, 4(4):409-419.
  2. Chung, W.O., J. Wataha, D. Hobbs, J. An, J. Wong, C. Park, M. Elvington and B. Rutherford.  2011.  Peroxotitanate and monosodium metal-titanate compounds as inhibitors of bacterial growth.  Journal of Biomedical Materials Research, 97(3):348-354.
  3. Chung, W.O., H. Dommisch and M.G. Rohani, in M. Fournier (Ed.), Perspectives on pattern recognition.  Nova Science Publishers, 2011.
  4. Chung, W.O., J.C. Wataha and D.T. Hobbs, in A. Mendez-Vilas (Ed.), Science against microbial pathogens: communicating current research and technological advances.  Formatex, 2011.
  5. Kretschmar, S., L. Yin, F.A. Roberts, R. London, T.T. Flemmig, D. Arushanov, K. Kaiyala and W.O. Chung.  2012.  Protease inhibitor levels in periodontal health and disease.  Journal of Periodontal Research, 47(2):228-35.
  6. Li, L., J. C. Wataha, C. Cate, H. Zhang, D. DiJulio and W.O. Chung.  2012.  Ni(II) alters the NFkB signaling pathway in monocytic cells.  Journal of Biomedical Materials Research, 100(4):934-939.
  7. Wataha, J.C., J.L. Drury and W.O. Chung.  2013.  Nickel alloys in the oral environment.  Expert Review of Medical Devices 10(4):519–539.
  8. Chung, W.O.  2013.  Therapeutic potentials of antimicrobial peptides.  Bioanalysis and Biomedicine.
  9. Chen, Y-W., J.L. Drury, W.O. Chung, D.T. Hobbs and J.C. Wataha.  2014.  Titanates and titanate-metal compounds in biological contexts.  Advances in Biomaterials.

Donald Chi

Background

  • AB, Government, Cornell University
  • DDS, Dentistry, University of Washington
  • PhD, Health Services Research, University of Iowa

Interests

  • Access to health care services
  • Pediatric health disparities
  • Neighborhoods and oral health outcomes
  • Social determinants of oral health

Selected Peer-Reviewed Publications

  1. Banks J, Hill C, Chi DL. Plan type and opioid prescriptions for children in Medicaid. Medical Care. Accepted.
  2. Lee JN, Scott JM, Chi DL. (2020). Oral health behaviors and dental caries in low-income children with special health care needs. International Journal of Paediatric Dentistry. Nov;30(6):749-757. PMID: 32306501. PMCID: none
  3. Chi DL, Coldwell S, Mancl L, Hopkins S, Senturia K, Randall C, Orr E, Cruz S. (2019). Alaska Native Children Do Not Prefer Sugar-Sweetened Fruit Drinks Compared to Sugar-Free Fruit Drinks. Journal of the Academy of Nutrition and Dietetics. Jun;119(6):984-990. PMID:30987919. PMCID: PMC6536342
  4. Chi DL, Rosenfeld M, Mancl L, Chung WO, Presland R, Sarvas E, Rothen M, McNamara S, Genatossio A, Virella-Lowell I, Milla C, Alkhateeb A. (2018). Age-Related Heterogeneity in Dental Caries and Associated Risk Factors in Individuals with Cystic Fibrosis Ages 6-20 years: A Pilot Study. Journal of Cystic Fibrosis. Nov;17(6):747-759. PMID: 30005828. PMCID: PMC6589399
  5. Chi DL, Momany E, Mancl L, Lindgren S, Zinner S, Steinman K. (2016). Dental homes for children with autism: a longitudinal analysis of Iowa Medicaid's I-Smile Program. American Journal of Preventive Medicine. May;50(5):609-15. PMID: 26514624. PMCID: PMC4838561

Jeffrey Scott McLean

Background

Dr. McLean’s research career began at the Pacific Northwest National Laboratory in Richland, WA (2000-2007). He then established a research program at the non-profit J. Craig Venter Institute in San Diego, CA in 2007. He moved to the University of Washington School of Dentistry in 2014 and is a tenured Associate Professor in the Department of Periodontics at the School of Dentistry with a joint appointment in Oral Health Sciences as well as an adjunct position in the Department of Microbiology at UW. For the past 21 years, his research has been primarily devoted to developing innovative methodologies, tools and new genomic based approaches to study microbial interactions within biofilm communities. Dr. McLean received his MSc at the University of Guelph in Canada and PhD at the University of Southern California. Currently, he is funded as a PI on multiple NIH awards to characterize the microbial processes that lead to oral diseases and maintain the health of the human oral microbiome.

The goal of the research in the McLean lab has been to gain an understanding for the molecular basis of bacteria-bacteria as well as bacteria-host interactions and further develop innovative methodologies, tools and integrated “omic” based approaches combined with wet-lab cultivation work on oral communities to ultimately translate this fundamental knowledge to the overall benefit of human health. His lab has extensive experience in next generation sequencing and combining omic approaches such as temporal resolved metatranscriptomic analysis (gene expression of all the microbes at once) in parallel with measuring global metabolites to reveal the homeostatic mechanisms of oral microbial communities. The lab tracks oral microbiome community assembly and maturation both in vitro and in vivo, capturing the temporal taxonomic and expression dynamics of key disease related species in direct association with the clinical host responses. Recent work of the team on the variation in human inflammatory responses to oral plaque bacteria leading to gum disease (gingivitis and chronic periodontitis) has links to overall systemic health.

McLean Research Lab Website

Schwedhelm
  • Latornell Travel Award
  • National Science and Engineering Research Council (NSERC) Industrial Postgraduate Scholarship
  • Outstanding Performance Award, Scientific contribution to the D.O.E. Genomes to Life Microbial Cell Project
  • Outstanding Performance Award, Dedication and recognition for contributions toward the Microbial Cell Dynamics Laboratory
  • 2 National Laboratory On the Spot Awards for outstanding performance
  • Outstanding Performance Award, Scientific contribution to an ACS article nominated one of top 4 articles of 2007.

2021

Saccharibacteria (2019)

 A Review of TM7 in the Human Oral Microbiome

Culturing TM7 (2018)

UW Health Sciences NewsBeat

Candidate Phylum TM7 and Periodontal Disease (Dec 2014-2015)

Novel genome of recovered from hospital (June 2013)

Science News from the Journal of Science

Single Cell genome of Periodontal Pathogen (2013)

The San Diego Union Tribune

*Corresponding Author #Co-first Author

  1. Shatha Bamashmous, Georgios A. Kotsakis, Kristopher A. Kerns, Brian G. Leroux, Camille Zenobia, Dandan Chen, Harsh M. Trivedi, Jeffrey S. McLean*, Richard P. Darveau. Human variation in gingival inflammation. Proceedings of the National Academy of Sciences (PNAS) Jul 2021, 118 (27) e2012578118; DOI: 10.1073/pnas.2012578118
  2. Lamont, E.I., Gadkari, A., Kerns, K.A., To, T.T., Daubert, D., Kotsakis, G., Bor, B., He, X., McLean, J.S.* Modified SHI medium supports growth of a disease-state subgingival polymicrobial community in vitro. Molecular Oral Microbiology. 2020 Nov 11. PubMed PMID: 33174294
  3. McLean, J.S.*, Bor, B., Kerns, K.A., Liu, Q., To, T.T., Solden, L., Hendrickson, E.L., Wrighton, K., Shi, W., and He, X. Acquisition and Adaptation of Ultra-small Parasitic Reduced Genome Bacteria to Mammalian Hosts. Cell Reports 32. 2020 July 21.https://doi.org/10.1016/j.celrep.2020.107939 PubMed PMID: 32698001
  4. Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein. Rapamycin rejuvenates oral health in aging mice. eLife, 2020; 9 DOI: 10.7554/eLife.54318  BioProject Accession No: PRJEB35672
  5. Bor B, Bedree JK, Shi W, McLean JS, He X.  Saccharibacteria (TM7) in the Human Oral Microbiome. J Dent Res. 2019 Mar 20:22034519831671. doi: 10.1177/0022034519831671. [Epub ahead of print] PubMed PMID: 30894042.
  6. Jain, S., Chang, A.M., Singh, M., McLean, J.S., Coats, S.R., Kramer, R.W. & Darveau, R.P. Identification of PGN_1123 as the gene encoding lipid A deacylase, an enzyme required for Toll-like receptor 4 evasion, in Porphyromonas gingivalis. J Bacteriol (2019). 2019 Feb 19. pii: JB.00683-18. doi: 10.1128/JB.00683-18.
  7. Chang AM, Liu Q, Hajjar AM, Greer A, McLean JS, Darveau Toll-like receptor-2 and -4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota. J Periodontol. 2019 Oct;90(10):1202-1212. doi: 10.1002/JPER.18-0719. Epub 2019 Jul 1. PubMed PMID: 31111967; PubMed Central PMCID: PMC6791728
  8. Coats SR, Kantrong N, To TT, Jain S, Genco CA, McLean JS, Darveau RP.  The distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and ATCC 33277 are determined by the fimB allele and gingipain activity. Infect Immun. 2019 Sep 30;. doi: 10.1128/IAI.00319-19. [Epub ahead of print] PubMed PMID: 31570556.
  9. Baker JL, Hendrickson EL, Tang X, Lux R, He X, Edlund A, McLean JS, Shi W.  Klebsiella and Providencia emerge as lone survivors following long-term starvation of oral microbiota. Proc Natl Acad Sci U S A. 2019 Apr 11. pii: 201820594. doi: 10.1073/pnas.1820594116. [Epub ahead of print] PubMed PMID: 30975748.
  10. Bor B, McLean JS, Foster KR, Cen L, To TT, Serrato-Guillen A, Dewhirst FE, Shi W, He X.  Rapid evolution of decreased host susceptibility drives a stable relationship between ultrasmall parasite TM7x and its bacterial host. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12277-12282. doi: 10.1073/pnas.1810625115. Epub 2018 Nov 15. PubMed PMID: 30442671
  11. Edlund, A., Yang, Y., Yooseph, S., He, X., Shi, W. & McLean, J.S*. Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation. Microbiome 6, 217 (2018) PMCID: PMC6284299
  12. Bor Batbileg, Jeffrey S. McLean, Kevin R. Foster, Lujia Cen, Thao T. To, Alejandro Serrato-Guillen, Floyd E. Dewhirst, Wenyuan Shi and Xuesong He. Rapid evolution of decreased host susceptibility drives a stable relationship between ultra-small parasite TM7x and its bacterial host. 2018. PNAS In Press Online Week of Nov 12th 2018
  13. Edlund A, Garg N, Mohimani H,Gurevich A, He X, Shi W, Dorrestein PC, McLean JS. 2017. Metabolic fingerprints from the human oral microbiome reveal a vast knowledge gap of secreted small peptidic molecules.
  14. M. Agnello, L. Cen, N.C. Tran, W.Shi, J.S. McLean*, X. He* Arginine Improves pH Homeostasis via Metabolism and Microbiome Modulation. Journal of Dental Research First published date: May-09-2017   10.1177/0022034517707512
  15. To TT, Liu Q, Watling M, Darveau RP, Bumgarner RE, McLean JS. Genome sequence of low-passage clinical isolate Porphyromonas gingivalis MP4-504. Genome Announcements
  16. McLean, J. S.*, Q. Liu, B. Bor, J. K. Bedree, L. Cen, M. Watling, T. T. To, R. E. Bumgarner, X. He and W. Shi (2016). “Draft Genome Sequence of Actinomyces odontolyticus subsp. actinosynbacter Strain XH001, the Basibiont of an Oral TM7 Epibiont.” Genome Announc 4(1).
  17. Guo, L.#, J. S. McLean#, Y. Yang, R. Eckert, C. W. Kaplan, P. Kyme, O. Sheikh, B. Varnum, R. Lux, W. Shi and X. He (2015). “Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology.” Proceedings of the National Academy of Sciences. published ahead of print June 1, 2015, doi:10.1073/pnas.1506207112 Role: #Co-First Author.   OPEN ACCESS
  18. Anna Edlund, Youngik Yang, Shibu Yooseph, Adam P. Hall, Don D. Nguyen, Pieter C. Dorrestein, Karen E. Nelson, Xuesong He, Renate Lux, Wenyuan Shi, Jeffrey S. McLean* Meta-Omics Uncover Temporal Regulation of Pathways Across Oral Microbiome Genera During in vitro Sugar Metabolism. (2105)  International Society for Microbial Ecology Journal (ISME)    OPEN ACCESS
  19. He, Xuesong#, McLean, Jeffrey S.#*(co-first author, co-corresponding author), Edlund, Anna, Yooseph, Shibu, Hall, Adam P., Liu, Su-Yang, Dorrestein, Pieter C., Esquenazi, Eduardo, Hunter, Ryan C., Cheng, Genhong, Nelson, Karen E., Lux, Renate, Shi, Wenyuan. (2015) Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle. Proceedings of the National Academy of Sciences 112(1):244-249. doi: 10.1073/pnas.1419038112.   OPEN ACCESS
  20. McLean JS* (2014) Advancements toward a systems level understanding of the human oral microbiome. Front Cell Infect Microbiol 4:98. PMCID: MC4114298
  21. Lasken RS & McLean JS (2014) Recent advances in genomic DNA sequencing of microbial species from single cells. Nat Rev Genet 15(9):577-584. PMID: 25091868
  22. Edlund, A., Yang, Y., Hall, A., Guo, L., Lux, R., He, X., Nelson, K., Nealson, K., Yooseph, S., Shi, W. & McLean, JS*. (2013) An in vitro biofilm model system maintaining a highly reproducible species and metabolic diversity approaching that of the human oral microbiome. Microbiome 1, 2
  23. McLean, JS*, M.-J. Lombardo, M. G. Ziegler, M. Novotny, J. Yee-Greenbaum, J. H. Badger, G. Tesler, S. Nurk, V. Lesin, D. Brami, A. P. Hall, A. Edlund, L. Z. Allen, S. Durkin, S. Reed, F. Torriani, K. H. Nealson, P. A. Pevzner, R. Friedman, J. C. Venter and R. S. Lasken (2013). “Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform.” Genome Research 23(5): 867-877. doi: 10.1101/gr.150433. PMCID: PMC3638142
  24. McLean, JS*, M.-J. Lombardo, J. H. Badger, A. Edlund, M. Novotny, J. Yee-Greenbaum, N. Vyahhi, A. P. Hall, Youngik Yang, C. L. Dupont, M. G. Ziegler, H. Chitsaz, A. E. Allen, S. Yooseph, G. Tesler, P. Pevzner, R. Friedman, K. H. Nealson, J. C. Venter and R. S. Lasken (2013). “Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum.” PNAS. Jun 25;110(26):E2390-9. doi: 10.1073/pnas.1219809110 PMCID: PMC3696752
  25. McLean, JS *, S. J. Fansler, P. D. Majors, K. McAteer, L. Z. Allen, M. E. Shirtliff, R. Lux, W. Shi (2012) Identifying Low pH Active and Lactate-Utilizing Taxa within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques. PLoS ONE, 7 (3), e32219. PMCID:PMC3293899
  26. McLean, JS*, O. N. Ona, and P. D. Majors. 2008. Correlated biofilm imaging, transport and metabolism measurements via combined nuclear magnetic resonance and confocal microscopy. ISME J 2:121 – 31.
  1. Utter, D.R., He, X., Cavanaugh, C.M., McLean, J.S., Bor., B. The saccharibacterium TM7x elicits differential responses across its hosts range. ISME 2020 Aug 24. https://doi.org/10.1038/s41396-020-00736-6
  2. Lamont, E.I., Hendrickson, E.L., McLean, J.S., He, X., Bor, B. Complete Genome Sequence of Strain BB001, a Novel Epibiont Bacterium from the Candidate Phylum Saccharibacteria (TM7) ASM. 2020 Aug 20.  https://doi.org/10.1128/MRA.00810-20 PubMed PMID: 32816985
  3. Bor B, Collins AJ, Murugkar PP, Balasubramanian S, To TT, Hendrickson EL, Bedree JK, Bidlack FB, Johnston CD, Shi W, McLean JS, He X, Dewhirst FE. Insights Obtained by Culturing Saccharibacteria With Their Bacterial Hosts. J Dent Res. 2020 Feb 19.   https://doi.org/10.1177/0022034520905792.  PubMed PMID: 32075512.
  4. Bedree Joseph K, Batbileg Bor, Lujia Cen, Anna Edlund, Renate Lux, Jeffrey S. McLean, Wenyuan Shi and   Xuesong He. Quorum Sensing Modulates the Epibiotic-Parasitic Relationship between Actinomyces odontolyticus and its Saccharibacteria epibiont, a Nanosynbacter lyticus strain, TM7x. Microbiol. | doi: 10.3389/fmicb.2018.02049
  5. Daubert D, Pozhitkov A, McLean J, Kotsakis G. Titanium as a modifier of the peri-implant microbiome structure. Clin Implant Dent Relat Res. 2018;1–9.   https://doi.org/10.1111/cid.12676
  6. Baker, J.L., Lindsay, E.L., Faustoferri, R.C., To, T.T., Hendrickson, E.L., He, X., Shi, W., McLean, J.S. & Quivey, R.G., Jr. Characterization of the trehalose utilization operon in Streptococcus mutans reveals that the TreR transcriptional regulator is involved in stress response pathways and toxin production. J Bacteriol (2018). J Bacteriol. 2018 Apr 9. pii: JB.00057-18. doi: 10.1128/JB.00057-18.
  7. Shen, M., Y. Yang, W. Shen, L. Cen, S. McLean, W. Shi, S. Le and X. He (2018). “A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly.” Appl Environ Microbiol 84(17).
  8. Torres PJ, Thompson J, McLean JS, Kelley ST, Edlund A. Discovery of a Novel Periodontal Disease-Associated Bacterium. Microb Ecol. 2018 Jun 2. doi: 10.1007/s00248-018-1200-6. [Epub ahead of print] PubMed PMID: 29860637.
  9. Shi, B., T. Wu, J. McLean, A. Edlund, Y. Young, X. He, H. Lv, X. Zhou, W. Shi, H. Li and R. Lux (2016). “The Denture-Associated Oral Microbiome in Health and Stomatitis.” mSphere 1(6).
  10. Harris, H. W., I. Sanchez-Andrea, S. McLean, E. C. Salas, W. Tran, M. Y. El-Naggar and K. H. Nealson (2017). “Redox Sensing within the Genus Shewanella.” Front Microbiol 8: 2568.
  11. Stanaway, I. B., J. C. Wallace, A. Shojaie, W. C. Griffith, S. Hong, C. S. Wilder, F. H. Green, J. Tsai, M. Knight, T. Workman, E. M. Vigoren, J. S. McLean, B. Thompson and E. M. Faustman (2017). “Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure.” Appl Environ Microbiol 83(2).
  12. Wang, M., et al. …. McLean, J. … P. C. Dorrestein and N. Bandeira (2016). “Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.” Nat Biotechnol 34(8): 828-837. Zhong, C., A. Edlund, Y. Yang, J. S. McLean and S. Yooseph (2016). “Metagenome and Metatranscriptome Analyses Using Protein Family Profiles.” PLoS Comput Biol 12(7): e1004991
  13. Bor B, Poweleit N, Bois JS, Cen L, Bedree JK, Zhou ZH, Gunsalus RP, Lux R, McLean JS, He X, Shi W. 2015. Phenotypic and Physiological Characterization of the Epibiotic Interaction Between TM7x and Its Basibiont Actinomyces. Microb Ecol doi:10.1007/s00248-015-0711-7:1-13.   http://link.springer.com/article/10.1007%2Fs00248-015-0711-7#
  14. Dmitry Antipov, Anton Korobeynikov, Jeffrey S. McLean, and Pavel A. Pevzner. HYBRIDSPADES: an algorithm for hybrid assembly of short and long reads. Bioinformatics first published online November 20, 2015 doi:10.1093/bioinformatics/btv688.
  15. Guo L, McLean JS, Lux R, He X, Shi W. 2015. The well-coordinated linkage between acidogenicity and aciduricity via insoluble glucans on the surface of Streptococcus mutans. Scientific Reports 5:18015.    http://dx.doi.org/10.1038/srep18015
  16. He, X., McLean, J.S., Guo, L., Lux, R. & Shi, W.(2013). The social structure of a microbial community involved in colonization resistance. ISME J. Online 3 October 2013 doi:10.1038 /ismej.2013.172 PMCID: PMC3930314  https://doi.org/10.1038/ismej.2013.172
  17. Guo, L., W. Hu, X. He, R. Lux, J. McLean and W. Shi (2013). “Investigating Acid Production by Streptococcus mutans with a Surface-Displayed pH-Sensitive Green Fluorescent Protein.” PLoS ONE 8(2): e57182. PMID: 23468929 PMCID: PMC3585301   http://www.plosone.org/article/authors/info%3Adoi%2F10.1371%2Fjournal.pone.0057182
  18. Allen LZ, Ishoey T, Novotny MA, McLean JS, Lasken RS, et al. (2011) Single Virus Genomics: A New Tool for Virus Discovery. PLoS ONE 6(3): e17722. doi:10.1371/journal.pone.0017722 PMID: 21436882 PMCID: PMC3059205 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017722
  19. Tian, Y.; He, X.; Torralba, M.; Yooseph, S.; Nelson, K. E.; Lux, R.; McLean, J. S.; Yu, G.; Shi, W. (2010) Using DGGE profiling to develop a novel culture medium suitable for oral microbial communities. Mol Oral Microbiol, 25 (5), 357-67. PMCID: PMC2951289   http://onlinelibrary.wiley.com/doi/10.1111/j.2041-1014.2010.00585.x/full
  20. McLean, J. S*.; Wanger G, Gorby YA, Wainstein M, McQuaid J, Ishii SI, Bretschger O, Beyenal H, Nealson KH (2010) Quantification of Electron Transfer Rates to a Solid Phase Electron Acceptor through the Stages of Biofilm Formation from Single Cells to Multicellular Communities. Environ Sci Technol 44: 2721-2727. PMID: 20199066  http://pubs.acs.org/doi/abs/10.1021/es903043p McLean, Jeff EST single cell es903043p
  21. McLean, J. S., Pinchuk, G. E., Geydebrekht, O. V., Bilskis, C. L., Zakrajsek, B. A., Hill, E. A., Saffarini, D. A., Romine, M. F., Gorby, Y. A., Fredrickson, J. K., and Beliaev, A. S., 2008. Oxygen-dependent autoaggregation in Shewanella oneidensis MR-1. Environ. Microbiol. Jul;10(7):1861-76. Epub 2008 Apr 10 doi:10.1111/j.1462-2920.2008.01608.x PMID: 18412550  http://onlinelibrary.wiley.com/doi/10.1111/j.1462-2920.2008.01608.x/abstract PDF
  22. McLean, J. S., P. D. Majors, C. L. Reardon, C.L. Bilskis, S.B. Reed, M. F. Romine and J. K. Fredrickson. (2007). “Investigations of structure and metabolism within Shewanella oneidensis MR-1 biofilms.” Journal of Microbiological Methods. 74: 47-56. 10.1016/j.mimet.2008.02.015
  23. Pinchuk, G. E., C. Ammons, D. E. Culley, S. M. Li, J. S. McLean, M. F. Romine, K. H. Nealson, J. K. Fredrickson, and A. S. Beliaev. ( 2007). Utilization of DNA as a Sole Source of Phosphorus, Carbon, and Energy by Shewanella: Ecological and Physiological Implications for Dissimilatory Metal Reduction. Appl Environ Microbiol. 74(4):1198-208.
  24. Gorby YA, S Yanina, JS McLean, KM Rosso, DM Moyles, A Dohnalkova, TJ Beveridge, I Chang, BH Kim, KS Kim, DE Culley, SB Reed, MF Romine, D Saffarini, EA Hill, L Shi, DA Elias, DW Kennedy, GE Pinchuk, K Watanabe, S Ishii, B Logan, KH Nealson, and JK Fredrickson. (2006). “Electrically conductive bacterial nanowires produced by Shewanella oneidensis strain MR-1 and other microorganisms.” Proceedings of the National Academy of Sciences of the United States of America 103(30):11358-11363.
  25. McLean JS, Beveridge TJ. (2001). Chromate reduction by a pseudomonad isolated from a site contaminated with chromated copper arsenate. Appl Environ Microbiol. Mar; 67(3):1076-84.
  26. McLean JS, Beveridge TJ, Phipps D. (2000). Isolation and characterization of a chromium-reducing bacterium from a chromated copper arsenate-contaminated site. Environ Microbiol. Dec; 2(6):611-9.
  1. Majors, P.D. and J.S. McLean. (2009). “Dynamic Metabolism Studies of Live Bacterial Films.” in Magnetic Resonance Microscopy. S. L. Codd and J. D. Seymour. Weinheim, Wiley-VCH.   http://dx.doi.org/10.1002/9783527626052 NLM Unique ID: 101511650
  2. McLean J.S., Lee JU, and Beveridge T.J.( 2001). Interactions of Bacteria and Environmental Metals, Fine-Grained Mineral Development and Bioremediation Strategies. In Interactions Between Soil Particles and Microorganisms and Their Impact on the Terrestrial Environment. (Ed. PM Huang) IUPAC Series on Analytical and Physical Chemistry of Environmental Systems. John Wiley and Sons. Ltd., UK.
  3. Mclean, J., T. Beveridge and D. Phipps. (1999) Chromate removal from contaminated groundwater using indigenous bacteria. In Bioremediation of Metals and Inorganic Compounds (Eds. A Leeson and B.C. Alleman). Proceedings of the In Situ and On Site Bioremediation . Fifth International Symposium. April 19-22, , San Diego. California, Battelle Press

Richard Darveau

Darveau
Bacteria/host interactions, LPS biochemistry, Host inflammatory response.
  1. Coats SR, Berezow AB, To TT, Jain S, Bainbridge BW, Banani KP, Darveau RP. 2011 The lipid A phosphate position determines differential host toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria. Infect Immun. Jan;79(1):203-10.
  2. Curtis MA, Percival RS, Devine D, Darveau RP, Coats SR, Rangarajan M, Tarelli E, Marsh PD. 2011  Temperature-Dependent Modulation of Porphyromonas gingivalis Lipid A Structure and Interaction with the Innate Host Defenses. Infect Immun. Mar;79(3):1187-93.
  3. Herath TD, Wang Y, Seneviratne CJ, Lu Q, Darveau RP, Wang CY, Jin L. 2011 Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts.  J Clin Periodontol. Aug;38(8):694-701.
  4. Hajishengallis, G. , Liang,S, Payne,M.A., Hashim, A., Jotwani,R., Eskan,M.A., McIntosh, M.L., Alsam,A., Kirkwood,K.L. Lambris,J.D., Darveau,R.P., and Curtis, M.A.  2011  A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway Cell Host Microbe. Oct 25.
  5. Darveau, R.P. 2009 The Oral Microbial Consortium’s Interaction  with the Periodontal Innate Defense System. DNA Cell Biol. 2009 Aug;28(8):389-95.
  6. Darveau, R.P. 2010 Periodontitis: a polymicrobial bacterially induced disruption of host homeostasis. Nat Rev Microbiol. Jun 1;8(7):481-490
  7. Jain S, Darveau RP. 2010 Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis. Periodontol 2000. 2010 Oct;54(1):53-70.
  8. Berezow AB, Darveau RP. 2011 Microbial shift and periodontitis. Periodontol 2000. Feb;55(1):36-47
  9. CurtisM.A.1, Zenobia, C2, and Richard P. Darveau2. 2011 The relationship of the oral microbiotia to periodontal health and disease. Cell Host Microbe. Oct 4;10(4):302-6.

Douglas Ramsay

Ramsay
Doug was born and raised in Pennsylvania where he received a B.A. in psychology from Franklin & Marshall College in 1979 and a D.M.D. from the University of Pennsylvania in 1983.  He came to the UW in 1983 as a senior fellow and in 1985 entered the UW’s NIH-funded Dentist-Scientist Training Program, which supported his doctoral studies in psychology (PhD, 1988) and specialty training in orthodontics (MSD, 1990).  He joined the UW faculty in 1990 and is currently Chair of the Department of Oral Health Sciences and the Associate Dean for Research and Faculty in the School of Dentistry.  

Doug is a professor of Orthodontics, Oral Health Sciences, Orthodontics, and Pediatric Dentistry.  In addition to receiving numerous NIH research grants, he was also the recipient of a Research Career Development Award from the National Institute of Dental and Craniofacial Research (NIDCR).  Doug is a Diplomate of the American Board of Orthodontics and a member of the Edward H. Angle Society of Orthodontists.  Doug is the Director of the UW’s Regional Clinical Dental Research Center and is currently the Director of the T90/R90 NIDCR-supported institutional training grant at the UW School of Dentistry.  Doug has directed courses in the predoctoral dental and graduate dental specialty programs, supervised patient care in the graduate orthodontics clinic, and been Chair of numerous thesis committees.

Dr. Ramsay teaches and supervises students at the undergraduate, graduate, and post-doctoral levels. Each year he directs a didactic seminar for the graduate students in Pediatric Dentistry and Orthodontics and provides guest lectures in other courses. As a board-certified orthodontist, he teaches and supervises patient care in the graduate orthodontics clinic throughout the year.

Dr. Ramsay’s research interests are broad and he has a record of conducting both basic and clinical research. A primary research interest of his is in the area of behavioral pharmacology with a focus on the mechanisms underlying the development of drug tolerance. His scientific interests include: mechanisms of drug tolerance, behavioral pharmacology, patient compliance, learning and memory, regulatory behavior, tooth circulation, addictive disorders, pain (mechanisms and psychophysics).

  1. Ramsay, D.S., Kaiyala, K.J and Woods, S.C. Individual Differences in Biological Regulation: Predicting Vulnerability to Drug Addiction, Obesity, and Other Dysregulatory Disorders.  Experimental and Clinical Psychopharmacology, 28, 388–403, 2020. [doi:10.1037/pha0000371].
  2. Ramsay, D.S. and Woods, S.C. Physiological regulation: How it really works.  Cell Metabolism, 24, 361-364, 2016.
  3. Ramsay, D.S., Rothen, M., Scott, J., and Cunha-Cruz, J; on behalf of the Northwest PRECEDENT network.  Tooth wear and the role of salivary measures in general practice patients.  Clinical Oral Investigations, 19, 85-95, 2015.
  4. Ramsay, D.S., Al-Noori, S., Shao, J., Leroux, B.G. and Woods, S.C., Kaiyala, K.J. Predicting addictive vulnerability: Individual differences in initial responding to a drug’s pharmacological effects.  PLoS ONE, 10(4), e0124740-e0124740, 2015. [doi: 10.1371/journal.pone.0124740].
  5. Ramsay, D.S. and Woods, S.C.  Clarifying the roles of homeostasis and allostasis in physiological regulation.  Psychological Review, 121 , 225-247, 2014.
  6. Ramsay, D.S., Woods, S.C. and Kaiyala, K.J.  Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors.  Temperature [Special Issue on Temperature and Toxicology with Focus on Drugs of Abuse], 1, 257-267, 2014.
  7. Ramsay, D.S., Woods, S.C. and Kaiyala, K.J.  Drug-induced regulatory overcompensation has motivational consequences: Implications for homeostatic and allostatic models of drug addiction.  Temperature [Special Issue on Temperature and Toxicology with Focus on Drugs of Abuse], 1, 248-256, 2014.
  8. Ramsay, D.S.  Patient compliance with oral hygiene regimens:  A behavioural self-regulation analysis with implications for technology.  International Dental Journal, 50, 304-311, 2000.
  9. Ramsay, D.S. and Woods, S.C.  Biological consequences of a drug administration:  Implications for acute and chronic tolerance.  Psychological Review, 104, 170-193, 1997.
  10. Ramsay, D.S., Årtun, J., and Martinen, S.S.  Reliability of pulpal blood flow measurements utilizing laser Doppler flowmetry.  Journal of Dental Research, 70, 1427-1430, 1991.

A complete list of Dr. Ramsay’s published work can be found in MyBibliography

Mark Drangsholt

Drangsholt
Dr. Drangsholt received his DDS degree from the University of Washington in 1984 and completed a general practice residency at Michael Reese Hospital and Medical Center in Chicago in 1985. He began a general dental practice in Kent, Washington, in 1985 where he continued to practice from half to full time until 1995. He returned to the University of Washington and earned his M.P.H. in Epidemiology in 1992, a certificate in Oral Medicine in 1995 and completed his PhD in Epidemiology in 2004. He was appointed as a tenure-track assistant professor in 2006 , was promoted to associate professor with tenure in 2009, and full professor in 2012. He was appointed Chair of the Department of Oral Medicine in 2010, and continues in that role. He served on the American Board of Oral Medicine from 2012 to 2021, serving in multiple roles including president. He received the Distinguished Alumni Award from the University of Washington School of Dentistry in 2019.
Dr. Drangsholt currently teaches in multiple medical/dental school and oral medicine graduate courses. He mentors Oral Medicine graduate students in various research projects. He has given over 150 presentations, including invited research presentations in Denmark, Germany, United Kingdom, Sweden, Thailand, and Australia, besides multiple universities across the US. He is the past president of the Neuroscience Section of the International Association for Dental Research, and past president of the University of Washington Dental Alumni Association.
Dr. Drangsholt provides patient care in the Oral Medicine Clinical Service department at the University of Washington, where his clinical practice is limited to the diagnosis and treatment of temporomandibular disorders, oral-facial pain, oral mucosal lesions, and other oral-facial diseases. He also provides care at the Center for Pain Relief, University of Washington Medical Center since 2011.
His current research projects include finding better ways to diagnose orofacial pains, investigating the causes of orofacial pain conditions, rethinking the classification of orofacial pains, and generally applying epidemiologic methods to major orofacial health problems. He has published over 90 peer-reviewed scientific articles, book chapters, reviews and letters to the editor.