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Patrick Stayton, PhD

Patrick Stayton

Professor, Bioengineering
Adjunct Professor, Oral Health Sciences

Office: 530L, Foege
Box: 351721


Our research group is interested in elucidating the fundamental mechanisms of biomolecular recognition and applying the unique capabilities of biological molecules to biotechnologies. We would like to bridge the gap between understanding molecular structure-function relationships, and being able to utilize proteins/peptides/DNA for drug therapies, bioanalytics, diagnostics, and biomaterial development.


  1. Drobny, G. P., Long, J. R., Karlsson, T., Shaw, W., Popham, J., Oyler, N., Bower, P., Stringer, J., Gregory, D., Mehta, M., and and Stayton, P. S. “Structural studies of biomaterials using double-quantum solid-state NMR Spectroscopy” (2003) Annual Reviews of Physical Chemistry, 54, 531-571.
  2. Stayton, P. S., Shaw, W. J., Long, J. R., and Drobny, G. P. (2003) “Molecular Recognition at the Protein-HAP Interface” Critical Reviews in Oral Biology and Medicine, 14, 370-376.
  3. Gilbert, M., Giachelli, C. M., and Stayton, P. S. (2003) “Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces” J. Biomed. Mat. Res., 67, 69-77.
  4. McDevitt, T. C., Woodhouse, K. A., Murry, C. E., Hauschka, S. D., and Stayton, P. S. (2003) “Spatially Organized Layers of Cardiomyocytes on Biodegradable Polyurethane Films for Myocardial Repair ” J. Biomed. Mat. Res. 66, 586-595.
  5. Stayton PS. (2003) “Delivering the Vaccination Mail” Trends Biotechnol. 21, 465-467.
  6. Malmstadt, N., Yager, P., Hoffman, A. S., and Stayton, P. S. (2003) “A Smart Microfluidic Affinity Chromatography Matrix Composed of Poly(N-isopropylacrylamide)-Coated Beads” Anal. Chem. (Accelerated Article) 75, 2943-2949.
  7. Murthy, N., Campbell, J., Fausto, N., Hoffman, A. S., and Stayton, P. S. (2003) “Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. ” J. Cont. Rel., 89, 365-74.
  8. Shimoboji, T., Larenas, E., Fowler, T., Kulkarni, S., Hoffman, A. S., and Stayton, P.S. (2002) “Photo-Responsive Polymer-Enzyme Switches” Proc. Natl. Acad. Sci. USA, 99, 16592-6.
  9. McDevitt, T. C., Angello, J. C., Whitney, M. L., Reinecke, H., Hauschka, S. D., Murry, C. E., and Stayton, P. S. (2002) ” In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces.” J. Biomed. Mat. Res. 60, 472-479.
  10. Ding, Z., Fong, R. B., Long, C. J., Hoffman, A. S. and Stayton, P. S. (2001) “Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield” Nature 411, 59-62.