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Jonathan An, DDS, PhD

Jonathan An

Assistant Professor, Oral Health Sciences
Assistant Graduate Program Director
Health Aging and Longevity Research Institute Faculty



Dr. An received his Bachelor of Science in Molecular, Cellular and Developmental Biology from the University of Washington. He completed a dual D.D.S (2015) and Ph.D (2019) from the University of Washington School of Dentistry. He is a UW Magnuson Scholar, ARCS Foundation Fellow, IADR/AADR Hatton Competition winner, and won the inaugural IADR Heraeus Award and ADA/Dentsply Sirona Research Award for Dual Degree Candidates.

Academic and Clinical Activities

Dr. An is currently an Assistant Professor of Oral Health Sciences and Faculty in the Healthy Aging and Longevity Institute. He also serves as the Assistant Graduate Program Director of Oral Health Sciences. Dr. An currently directs courses in the departments of Oral Health Sciences and the Department of Lab Medicine and Pathology.

Research Interests

Dr. An’s research interests lie at the intersection of Geroscience (aging biology) and Oral Biology. His primary research focuses on understand the basic biological mechanisms of aging in the context of oral health and disease.  His laboratory also evaluates and targets specific hallmarks of aging in the oral cavity to one day translate these discoveries to help extend the oral healthspan in humans.

Recent Publications

  1. Buranaphatthana, W.; Yavirach, A.;  Leaf, E. M.;  Scatena, M.;  Zhang, H.;  An, J. Y.; Giachelli, C. M., Engineered osteoclasts resorb necrotic alveolar bone in anti-RANKL antibody-treated mice. Bone 2021, 153, 116144.
  2. An JY, Kerns KA, Ouellette A, Robinson L, Morris HD, Kaczorowski C, Park SI, Mekvanich T, Kang A, McLean JS, Cox TC, Kaeberlein M. Rapamycin rejuvenates oral health in aging mice. Elife. 2020 Apr 28;9. PMID: 32342860; PMCID: PMC7220376.
  3. An JY, Darveau R, Kaeberlein M. Oral health in geroscience: animal models and the aging oral cavity. Geroscience. 2018 Feb;40(1):1-10. PMID: 29282653; PMCID: PMC5832657.
  4. An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M. Rapamycin treatment attenuates age-associated periodontitis in mice. Geroscience. 2017 Aug;39(4):457-463. PMID: 28889220; PMCID: PMC5636779.
  5. Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M. Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Front Genet. 2017;8:113 PMID: 28919908; PMCID: PMC5585733.
  6. Chung WO, Wataha JC, Hobbs DT, An J, Wong JJ, Park CH, Dogan S, Elvington MC, Rutherford RB. Peroxotitanate- and monosodium metal-titanate compounds as inhibitors of bacterial growth. J Biomed Mater Res A. 2011 Jun 1;97(3):348-54. PubMed PMID: 21472975.
  7. Rohani MG, DiJulio DH, An JY, Hacker BM, Dale BA, Chung WO. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes. BMC Immunol. 2010 Oct 28;11:53. PMID: 21029417; PMCID: PMC2988058.
  8. Chung WO, An JY, Yin L, Hacker BM, Rohani MG, Dommisch H, DiJulio DH. Interplay of protease-activated receptors and NOD pattern recognition receptors in epithelial innate immune responses to bacteria. Immunol Lett. 2010 Jul 8;131(2):113-9. PubMed PMID: 20219537; PubMed Central PMCID: PMC2885501.
  9. Yin L, Swanson B, An J, Hacker BM, Silverman GA, Dale BA, Chung WO. Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2. J Oral Microbiol. 2010 May 4;2.PMID: 21523231; PMCID: PMC3084571.