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UW School of Dentistry

Department: OHS Adjunct

Alvin G. Wee

Wee
  • Bachelor of Dental Surgery (BDS), National University of Singapore – 1992
  • Certificate in Prosthodontics, The University of Iowa – 1996
  • Master of Science (MS), The University of Iowa – 1997
  • Certificate in Maxillofacial Prosthetics, University of Pittsburgh – 1998
  • Certificate in Clinical Research/NIH K30, The Ohio State University – 2002
  • Master of Public Health (MPH), The Ohio State University – 2005
  • Doctor of Dental Surgery (DDS), Creighton University – 2013
  • Doctor of Philosophy (PhD), University of Nebraska – 2014 

Dr. Wee started his professional career at The Ohio State University College of Dentistry, where he was eventually promoted to Associate Professor with tenure. His academic career continued at the University of Nebraska Medical Center (Department of Otolaryngology – Head and Neck Surgery) and Creighton University (Department of Prosthodontics). In 2014, he took a break from academia and accepted a position at the Veterans Affairs Nebraska-Western Iowa Health Care System in Omaha, Nebraska, where he served as Assistant Dental Service Chief and Dental Laboratory Supervisor. He returned to academics in 2019 as Professor (with tenure) and Director of the Division of Prosthodontics at the University of Minnesota. He started his tenure at the University of Washington in July 2024.

Dr. Wee has received research funding as principal investigator (NIH R15 and NIH K23) and co-investigator (NIH R01 and VA RR&D) from the National Institutes of Health, Department of Veteran’s Affairs, as well as several other agencies. Dr. Wee has authored more than 100 peer-reviewed publications and several textbook chapters.

His research foci are:
(1) Major: Clinical translational aspects of color science with regard to teeth/skin and their respective restorative materials
(2) Minor: Early detection of oral and oropharyngeal cancer
(3) Minor: Educational research in the area of restorative dentistry and prosthodontics

  • National Recipient of the Clinical Excellence in Dentistry Award, Department of Veteran’s Affairs
  • Inducted into Epsilon Chapter of Omicron Kappa Upsilon (OKU), National Dental Honor Society
  • Inaugural Claude R. Baker Teaching Award for Excellence in Teaching Predoctoral Fixed Prosthodontics, American Academy of Fixed Prosthodontics
  • The Ohio State Fisher College/Deloitte Touche Business Plan Competition, Second Place, The Ohio State University
  • Student Government Teaching Award, The Ohio State University College of Dentistry
  • Clinical Instructor of the Year , The Alpha Omega Professional Dental Fraternity
  • Honored Hooder, The Ohio State University Graduating Dental Class
  • Multi-Year Ambassadorial Scholarship, Rotary International Foundation
  • Silver Jubilee Award, National University of Singapore Dental Society 

Dr. Wee currently holds the following offices: (1) President of the American Academy of Maxillofacial Prosthetics, and (2) Honorary Treasurer of the International Academy of Oral and Facial Rehabilitation. He also sits on the Board of Directors for the American College of Prosthodontists as the Director of the Prosthodontic Forum. Dr. Wee is one of three Assistant Editors of the Journal of Prosthetic Dentistry and has reviewed for more than 20 peer-reviewed journals. He is also an external examiner for the National University of Singapore and Hong Kong University. He has been invited to deliver more than 100 presentations both nationally and internationally on various aspects of dentistry.

Dr. Wee continues to be affiliated with the Veterans Affairs Health Care System for his faculty practice, where he treats patients with complex oral rehabilitation needs, including those with head and neck cancer, facial trauma, and obstructive sleep apnea.

Paul Yager

Yager
Paul Yager, a native of Manhattan, received his A.B. in Biochemistry from Princeton in 1975, and a Ph.D. in Chemistry from the University of Oregon in Eugene in 1980. He specialized in vibrational spectroscopy of biomolecules. He was a National Research Council Resident Research Associate at the Naval Research Laboratory in Washington, DC from 1980 to 1982, joining the staff of NRL as a Research Chemist in 1982. At NRL he focused on lipid microstructures and the development of biosensor technologies. He joined the faculty of the Department of Bioengineering at the University of Washington in Seattle in 1987 as Associate Professor.

Initial projects included work on biosensors, the structure of silk, and use of lipid microstructures for controlled release of pharmaceuticals. He was promoted to Professor in 1995, becoming Vice Chair in 2001. Since 1992, Yager has focused on development of microfluidic devices for the manipulation of biological fluids and the measurement of concentrations of analytes of biological relevance. Support to his laboratory and collaborators has been received from NSF, NIH, DARPA, The Whitaker Foundation, the government of Singapore, and private companies including MesoSystems, Senmed Medical Ventures and Hewlett Packard. The support from Senmed resulted in the creation of Micronics, Inc., a Redmond, WA-based company dedicated to microfluidic solutions for problems in the life sciences and medicine.

The primary goal of current work in his laboratory is decentralization of biomedical diagnostic testing in the developed and developing worlds through a program called Distributed Diagnosis and Home Healthcare. The specific aim is the development of microfluidic devices and systems for optical bioassays. Learn more about Paul Yager.

  1. Microcontact printed antibodies on gold surfaces: function, uniformity, and silicone contamination, Foley, J., Fu, E., Gamble, L. and Yager, P., Langmuir, 24(7):3628–3635 (2008)
  2. Experimental and model investigation of the time-dependent 2-dimensional distribution of binding in a herringbone microchannel , Foley, J.O., Mashadi-Hossein, A., Fu, E., Finlayson, B.A., and Yager, P., Lab on a Chip, 8(4): 557–564 (2008)
  3. Point-of-care diagnostics for global health. Yager , P., Domingo , G.J., and Gerdes, J., Annual Review of Biomedical Engineering, 10: 107–144 (2008)
  4. A method for characterizing adsorption of flowing solutes to microfluidic device surfaces, Hawkins, K. R., Steedman, M. R., Baldwin, R. R., Fu, E., Ghosal, S., and Yager, P., Lab on a Chip, 7(2), 281–285 (2007)
  5. SPR imaging-based salivary diagnostics system for the detection of small molecule analytes, Fu, Elain, Chinowsky, T., Nelson, K., Johnston, K., Edwards, T., Helton, K., Grow, J., Miller, J. W., and Yager, P., Ann. N.Y. Acad. Sci. 1098: 335–344 (2007)
  6. Concentration gradient immunoassay I. a rapid immunoassay based on interdiffusion and surface binding in a microchannel, Nelson, K. E., Foley, J. O., and Yager, P., Analytical Chemistry, 79(10): 3542–3548 (2007)
  7. Concentration gradient immunoassay II. computational modeling for analysis and optimization, Foley, J. O., Nelson, K. E., Mashadi-Hossein, A., Finlayson, B.A., and Yager, P. Analytical Chemistry, 79(10): 3549–3553 (2007)
  8. Investigation of heterogeneous electrochemical processes using multi-stream laminar flow in a microchannel, Hasenbank, M. S., Fu, E., Nelson, J. B., Schwartz, D. T., and Yager, P., Lab on a Chip, 7(4): 441–447 (2007)
  9. Interfacial instabilities affect microfluidic extraction of small molecules from non-Newtonian fluids, Helton, K.L. and Yager, P., Lab on a Chip, 7(11):1581–1588 (2007)
  10. Microfluidic lab-on-a-chip for microbial identification on a DNA microarray, Lee, H.H. and Yager, P., Biotechnology and Bioprocess Engineering, 12:634–639 (2007)
  11. Microfluidic diagnostic technologies for global public health, Yager, P., Edwards, T., Fu, E., Helton, K., Nelson, K., Tam, M. and Weigl, B., Nature, 442(7101). 412–418 (2006)
  12. One-dimensional surface plasmon resonance imaging system using wavelength interrogation, Fu, E., Ramsey, S., Thariani, R., and Yager, P., Review of Scientific Instruments, 77 (7): Art. No. 076106 (2006)
  13. Recirculating flow accelerates DNA microarray hybridization in a microfluidic device, Lee, H.H., Smoot, J., McMurray, Z., Stahl, D. A., and Yager, P., Lab on a Chip, 6 (9): 1163–1170 (2006)
  14. Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer, Munson, M.S. and Yager, P., Analytica Chimica Acta, 501(1), 63-71 (2004)
  15. Controlled microfluidic reconstitution of functional protein from an anhydrous storage depot, Garcia, E., Kirkham, J. R., Hatch, A.V, Hawkins, K.R. and Yager, P., Lab on a Chip, 4, 78-82 (2004)
  16. Characterization of a wavelength-tunable surface plasmon resonance microscope, Fu, E., Chinowsky T., Foley, J., Weinstein J., and Yager, P., Review of Scientific Instruments, 75(7), 2300-2304 (2004).
  17. Diffusion-based analysis of molecular interactions in microfluidic devices, Hatch, A., Garcia, E. and Yager, P., IEEE Proceedings, 92(1), 126-139 (2004)
  18. Suppression of non-specific adsorption using sheath flow, Munson, M. S., Hasenbank, M. S., Fu, E. and Yager, P., Lab on a Chip, 4, 438-445 (2004).

Patrick Stayton

Interests

Our research group is interested in elucidating the fundamental mechanisms of biomolecular recognition and applying the unique capabilities of biological molecules to biotechnologies. We would like to bridge the gap between understanding molecular structure-function relationships, and being able to utilize proteins/peptides/DNA for drug therapies, bioanalytics, diagnostics, and biomaterial development.

Publications

  1. Drobny, G. P., Long, J. R., Karlsson, T., Shaw, W., Popham, J., Oyler, N., Bower, P., Stringer, J., Gregory, D., Mehta, M., and Stayton, P. S. “Structural studies of biomaterials using double-quantum solid-state NMR Spectroscopy” (2003) Annual Reviews of Physical Chemistry, 54, 531-571.
  2. Stayton, P. S., Shaw, W. J., Long, J. R., and Drobny, G. P. (2003) “Molecular Recognition at the Protein-HAP Interface” Critical Reviews in Oral Biology and Medicine, 14, 370-376.
  3. Gilbert, M., Giachelli, C. M., and Stayton, P. S. (2003) “Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces” J. Biomed. Mat. Res., 67, 69-77.
  4. McDevitt, T. C., Woodhouse, K. A., Murry, C. E., Hauschka, S. D., and Stayton, P. S. (2003) “Spatially Organized Layers of Cardiomyocytes on Biodegradable Polyurethane Films for Myocardial Repair ” J. Biomed. Mat. Res. 66, 586-595.
  5. Stayton PS. (2003) “Delivering the Vaccination Mail” Trends Biotechnol. 21, 465-467.
  6. Malmstadt, N., Yager, P., Hoffman, A. S., and Stayton, P. S. (2003) “A Smart Microfluidic Affinity Chromatography Matrix Composed of Poly(N-isopropylacrylamide)-Coated Beads” Anal. Chem. (Accelerated Article) 75, 2943-2949.
  7. Murthy, N., Campbell, J., Fausto, N., Hoffman, A. S., and Stayton, P. S. (2003) “Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. ” J. Cont. Rel., 89, 365-74.
  8. Shimoboji, T., Larenas, E., Fowler, T., Kulkarni, S., Hoffman, A. S., and Stayton, P.S. (2002) “Photo-Responsive Polymer-Enzyme Switches” Proc. Natl. Acad. Sci. USA, 99, 16592-6.
  9. McDevitt, T. C., Angello, J. C., Whitney, M. L., Reinecke, H., Hauschka, S. D., Murry, C. E., and Stayton, P. S. (2002) ” In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces.” J. Biomed. Mat. Res. 60, 472-479.
  10. Ding, Z., Fong, R. B., Long, C. J., Hoffman, A. S. and Stayton, P. S. (2001) “Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield” Nature 411, 59-62.

Paul Nghiem

Research Interests

Skin cancer biology, particularly the molecular mechanism by which the protein kinase ATR mediates an essential cell cycle arrest following DNA damage such as by ultraviolet radiation.

A major portion of the lab is focused on basic, clinical and translational research aspects of Merkel cell carcinoma. We are involved in several clinical studies on this increasingly common and often lethal skin cancer to determine its basic genetic underpinnings as well as its clinical course and optimal management. The Merkel cell carcinoma Multicenter Interest Group (MMIG), an international collaborative group, has been formed to leverage diverse resources, interests and expertise to make a difference in this cancer.

Publications

  1. Boswell SA, Ongusaha PP, Nghiem P, Lee SW. The Protective Role of a Small GTPase RhoE Against UVB-induced DNA Damage in Keratinocytes. J Biol Chem. 282(7):4850-4858, 2007.
  2. *Kawasumi M, Nghiem P.  Chemical genetics: Elucidating biological systems with small molecules.  J Invest Dermatol. 127(7):1577-84, 2007.
  3. *Koo S-W, Hirakawa S, Fujii S, Kawasumi M, Nghiem P.  Protection from photodamage by topical application of caffeine after UV. Br J Dermatol. 156:957, 2007.
  4. *Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH. Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice. Can Res. 68(7):2523-2529, 2008.
  5. *Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P.  ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine.  J Invest Dermatol. 2009.
  6. * Lemos B, Storer B, Iyer J, Phillips JL, Bichakjian CK, Fang LC, Johnson TM, Liegeois-Kwon NJ, Otley CC, Paulson KG, Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald JE, Sober AJ, Nghiem P. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5,823 cases as the basis of the first consensus staging system for this cancer. J Am Acad Dermatol. 2010. [PubMed]
  7. Kelly G. Paulson*, Joseph J. Carter*, Lisa G. Johnson, Kevin W. Cahill, Jayasri G. Iyer, David Schrama, Juergen C. Becker, Margaret M. Madeleine, Paul Nghiem**, Denise A.Galloway**. Antibodies to Merkel cell polyomavirus T-antigen oncoproteins reflect Merkel cell carcinoma tumor burden. Can Res. 2010. [PubMed]
  8. Kelly G. Paulson, Jayasri G. Iyer, Paul Nghiem. Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States. J Am Acad Dermatol. 2011.

Cecilia Giachelli

Interests

Current projects include:

  • Identifying and applying biomimetic strategies to cell-substrate interactions important for promoting endothelial survival and angiogenesis particularly in the context of biomaterial healing,
  • Biomolecular control of the foreign body reaction, with particular emphasis on the macrophage-mediated inflammatory response to biomaterials
  • Mechanistic studies aimed at developing novel therapeutic targets and approaches for preventing ectopic calcification in disease and medical devices
  • Cardiac valve and esophageal tissue engineering.

Publications

  1. Rajachar R, Truong A, Giachelli CM. The influence of surface mineral and osteopontin on the formation and function of murine bone marrow macrophage derived osteoclasts, J Biomed Mater Res, J Mater Sci Mat med, 2008.
  2. M. Linnes, B.D. Ratner, C.M. Giachelli. A Fibrinogen Based Precision Microporous Scaffold for Tissue Engineering: Development and Characterization. Biomaterials, 28(35):5298-306, 2007.
  3. Beckstead, B.L. and C.M. Giachelli. “Mimicking cell-cell interactions at the biomaterial-cell interface” J Biomed Mater Res A. 2006 Oct; 79(1):94-103.
  4. Li X, Ying-Yang H, Giachelli CM. Role of the Sodium Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Calcification. Circ Res. 2006 98:905-12, 2006.
  5. Tsai A, Rice J, Liaw L, Ratner B, Giachelli CM. Osteopntin reduces foreign body giant cell formation in response to biomaterial implantation. Biomaterials, 26:5835-43, 2005.
  6. Ohri R, Tung E, Rajachar R, Giachelli CM. Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin: efficacy, potency and mechanism. Calcified Tissue Intl, 76:307-15, 2005.
  7. Cuy JL, Beckstead BL, Brown CD, Hoffman AS, Giachelli CM. Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. J Biomed Mater Res, 67A: 538-547, 2003.
  8. Wiester LM, Giachelli CM. Expression and function of the integrin, a9b1, in bovine aortic valve interstitial cells. J Heart Valve Disease, 12: 605-616, 2003.
  9. Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E, Karsenty G, Giachelli CM. Inactivation of the osteopontin gene enhances vascular calcification of matrix gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 196: 1047-1055, 2002.
  10. Steitz SA, McKee MD, Liaw L, Giachelli CM. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Amer J Path 16:2035-2046, 2002.

Albert Folch

Interests

We design and use microfluidic devices to better mimic the real microenvironment of nerve and cancer cells when we culture them outside of the organism. We are microfluidic!​​ ​Examples of questions that interest us are how neurons find their targets during development (axon guidance​), how they establish their connections (synaptogenesis​), and how we sense odors (olfaction​), among other projects. We also build microfluidic devices that allow us to personalize chemotherapy ​and devices to study cancer stem cells​​​.

Publications

  1. K.W. Moyes, C.G. Sip, W. Obenza, E. Yang, C. Horst, R.E. Welikson, S.D. Hauschka, A. Folch, and M. Laflamme, “Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a”, Stem Cells and Development 22, 1 (2013). Human embryonic stem cell-derived cardiomyocytes show robust promigratory responses to microfluidic gradients of fibronectin and Wnt5a.
  2. Adina Scott, Anthony K. Au, Elise Vinckenbosch, and Albert Folch, “A microfluidic D-subminiature connector”, Lab on a Chip 13, 2036 (2013). We present a novel microfluidic connector based on standard electronic components that are available worldwide.
  3. Peder Skafte-Pedersen, Christopher G. Sip, Albert Folch, and Martin Dufva, “Modular microfluidic systems using reversibly attached PDMS fluid control modules”, Journal of Micromech. Microeng. 23, 055011 (2013). We demonstrate the integration of PDMS-based fluid control modules with hard polymer chips made of PMMA.
  4. Scott, A., Weir, K., Easton, C., Huynh, W., Moody, W.J., and Folch, A., “A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices”, Lab Chip 13, 527 (2013). We demonstrate electrophysiological recordings from the surface of brain slices using a PDMS device featuring multiple apertures that function as extracellular electrodes as well as chemical stimulation points.
  5. A. K. Au, H. Lai, B. R. Utela, and A. Folch, “Microvalves and Micropumps for BioMEMS”, Micromachines 2, 179 (2011). An in-depth review of the designs of micropumps and microvalves that have been used in the BioMEMS literature.
  6. C. G. Sip, N. Bhattacharjee, and A. Folch, “A Modular Cell Culture Device for Generating Arrays of Gradients Using Stacked Microfluidic Flows”, Biomicrofluidics 5, 022210 (2011). This device reports a microfluidic gradient generator for cell culture applications based on the use of stacked laminar flows.
  7. Hoyin Lai and Albert Folch, “Design and characterization of “single-stroke” peristaltic PDMS micropumps”, Lab Chip 11, 336 (2011). We demonstrate a new design of PDMS peristaltic pumps operated with a single control line.
  8. Anna Boardman, Tim Chang, Albert Folch, and Norman J. Dovichi, “Indium-Tin Oxide Coated Microfabricated Device for the Injection of a Single Cell into a Fused Silica Capillary for Chemical Cytometry”, Analytical Chemistry 82, 9959 (2010). We describe a microfabricated device for the capture and injection of a single mammalian cell into a fused silica capillary for subsequent analysis by chemical cytometry.
  9. Nirveek Bhattacharjee, Nianzhen Li, Thomas M. Keenan, and Albert Folch, “A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors”, Integrative Biology 2, 669 (2010). We record axonal growth of mouse embryonic cortical neurons in response to netrin gradients generated with a low-shear, open-bath microfluidic device.
  10. David M. Cate, Christopher Sip, and Albert Folch, “A microfluidic platform for generation of sharp gradients in open-access culture”, Biomicrofluidics 4, 044105 (2010). We demonstrate a membrane-based gradient generator that is compatible with open cell cultures.
  11. John M. Hoffman, Mitsuhiro Ebara, James J. Lai, Allan S. Hoffman, Albert Folch, and Patrick Stayton, “A helical flow, circular microreactor for separating and enriching “smart: polymer-antibody capture reagents”, Lab Chip 10, 3130 (2010). We report a mechanistic study of how flow and recirculation in a microreactor can be used to optimize the capture and release of stimuli-responsive polymer–protein reagents on stimuli-responsive polymer-grafted channel surfaces.
  12. Ellen Tenstad, Anna Tourovskaia, Albert Folch, Ola Myklebost, and Edith Rian, “Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device”, Lab Chip 10, 1401 (2010).–> Inside cover article.  Adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells is demonstrated using long-term microfluidic perfusion.
  13. Figueroa, X.A., Cooksey, G.A., Votaw, S.V., Horowitz, L.F., and Folch, A., “Large-scale investigation of the olfactory receptor space using a microfluidic microwell array”, Lab Chip 10, 1120 (2010). –> Cover article & Cited in Chemical Technology Highlights section. We show simultaneous calcium recordings of mouse dissociated olfactory sensory neurons in large microarrays so that the whole repertoire of mouse olfactory receptors is probed in one experiment.
  14. Keenan, T.M., Frevert, C.W., Wu, A., Wong, V., and Folch, A., “A New Method for Studying Gradient-Induced Neutrophil Desensitization Based on an Open Microfluidic Chamber”, Lab Chip 10, 116 (2010). This paper demonstrates neutrophil chemotaxis measurements in an open microfluidic chamber.
  15. Sidorova, J.M. Li, N., Schwartz, D.C., Folch, A., and Monnat Jr., R.J. “Microfluidic-assisted analysis of replicating DNA molecules”, Nature Protocols 4, 849 (2009). This paper presents detailed protocols on how to stretch DNA on glass surfaces using microfluidic channels.

Michael Cunningham

Background

Michael L. Cunningham, MD, PhD, is chief of the Division of Craniofacial Medicine and professor of pediatrics at the University of Washington School of Medicine. He is the medical director of Seattle Children’s Craniofacial Center and holds the Jean Renny Endowed Chair in Craniofacial Medicine. He is also an adjunct professor of Biological Structures, Oral Biology, and Pediatrics Dentistry at the University of Washington Schools of Medicine and Dentistry. Dr. Cunningham balances responsibilities in administration, patient care and research. He does bedside teaching of medical students, dental students and pediatric residents. His clinical interests focus on the diagnosis and long-term interdisciplinary care of children with craniofacial malformations with a particular interest in craniosynostosis. He is co-investigator on several clinical research projects, ranging from the epidemiology of positional plagiocephaly to the risk factors for obstructive sleep apnea. Dr. Cunningham’s basic molecular and developmental biology lab has been active since 1993. Using mouse and human models Dr. Cunningham’s research team investigate the molecular causes of craniosynostosis and developmental pathogenesis of midface hypoplasia associated with syndromic craniosynostosis.

Publications

  1. Speltz ML, Collett B, Stott-Miller M, Starr JR, Heike CL, Wolfram-Aduan A, King D, Cunningham ML. Case-control study of neurodevelopment in infants with deformational plagiocephaly.Pediatrics. 2010 Feb 15. [Epub ahead of print] PubMed PMID:20156894.
  2. Hing AV, Click E, Vessey K, Seto M, Holder U, Gruss J, Hopper R, Cunningham ML. Bilateral lambdoid and sagittal synostosis (BLSS): a unique craniosynostosis syndrome or predictable phenotype? Am J Med Genet A 2009; 149A(5):1024-1032.
  3. Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Sze RW, Ellenbogen RG, Speltz ML, Cunningham ML. New severity indices for quantifying single-suture metopic craniosynostosis. Neurosurgery2008; 63(2):318-24; discussion 324-5.
  4. Cunningham ML, Seto ML, Ratisoontorn C, Heike CL, Hing AV. Syndromic craniosynostosis: from history to hydrogen bonds. Orthod Craniofac Res (Invited review) 2007; 10:67–81.
  5. Seto ML, Hing AV, Chang J, Hu M, Kapp-Simon KA, Patel PK, Burton BK, Kane A, Smyth MD, Hopper R, Ellenbogen RG, Stevenson K, Speltz ML, Cunningham ML. Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations. Am J Med Genet A 2007; 143:678-686.
  6. Hatch NE, Hudson M, Seto ML, Cunningham ML, Bothwell M. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J Biol Chem 2006; 281(37):27292-27305.
  7. Cunningham ML, Seto ML, Hing AV, Bull MJ, Hopkin RJ, Leppig KA. Cleidocranial dysplasia with severe parietal bone dysplasia: C-terminal RUNX2 mutations. Birth Defects Res A Clin Mol Teratol2006; 76(2):78-85.
  8. Ratisoontorn C, Seto ML, Broughton KM, Cunningham ML. In-vitro differentiation profile of osteoblasts derived from patients with Saethre-Chotzen syndrome. Bone 2005; 36(4):627-634.
  9. Heike CL, Seto M, Hing AV, Palidin A, Hu FZ, Preston RA, Ehrlich GD, Cunningham ML. A century of Jackson-Weiss syndrome: further definition of clinical and radiographic findings in ‘lost’ descendants of the original kindred. Am J Med Genet 2001; 100(4):315-324.
  10. Dry GM, Yasinskaya YI, Williams JK, Erhlich G, Preston R, Gruss JS, Ellenbogen RG, Cunningham ML. Inhibition of apoptosis: a potential mechanism for syndromic craniosynostosis. Plast Reconstr Surg 2001; 107(2):425-432.

Christy McKinney

McKinney

Christy McKinney, PhD, MPH is an Associate Professor in Craniofacial Medicine, Pediatrics in the School of Medicine and an Adjunct Associate Professor in Oral Health Sciences, School of Dentistry. She is also an investigator in Seattle Children’s Research Institute’s Center for Child Health, Behavior and Development, and in the Seattle Children’s Hospital Craniofacial Center. She received her PhD (2006) in epidemiology from the University of Washington.

Dr. McKinney’s research interests are focused on the intersection of craniofacial, oral, and nutritional health in young children, both locally and globally. She is the principal investigator of a R01 grant from NIDCR investigating the extent to which children are exposed to the chemical Bisphenol A (BPA) during dental treatment. She also spearheaded the development of the NIFTY™ cup –  an infant feeding cup for infants with breastfeeding difficulties (e.g. infants with oral clefts and preterm infants) in low resource settings – with a team of multidisciplinary experts from Seattle Children’s, the University of Washington, PATH, and Laerdal Global Health with clinical testing at Sri Ramachandra University, India.

Dr. McKinney is also the Director of the Summer Institute in Clinical Dental Research Methods at the University of Washington, School of Dentistry and Associate Director of the Institute of Translational Sciences (ITHS) KL2 Career Development program, which trains career development KL2 Scholars through weekly seminars and small group sessions.

 

  1. McKinney CM, Pisek A, Chowchuen B, Pisek A, DeRouen T, Muktabhant B, Yeung C, Pitiphat W. A case control study of nutritional and environmental factors and the risk of oral clefts. Birth Defects Research Part A: Clinical and Molecular Teratology, 2016, Vol. 106, pp.624-632.
  2. McKinney CM, Glass R, Coffey P, Rue T, Cunningham M. Feeding neonates and young infants by cup: A systematic review of the literature. Maternal and Child Health Journal, 2016, Vol. 20, No. 8, pp.1620-1633.
  3. McKinney CM, Rue T, Sathyanarayana S, Martin M, Seminario AL, DeRouen T.   Dental Sealants and Urinary Bisphenol A Concentrations in Children in the 2003-2004 NHANES. Journal of the American Dental Association, 2014, Vol. 145, No. 7, pp.745-50.
  4. Nirunsittirat, A*, Pitiphat, W, McKinney CM, DeRouen, TA, Chansamak N, Angwaravong, O, Patcharanuchat P, Pimpak T. Breastfeeding duration and childhood caries: a cohort study. Caries Research, 2016, Vol 50, No. 5, pp. 498-507.
  5. Seattle Children’s Hospital 2015 Academic Report. Inquiry to Action. Low-Tech Fix to Deadly Issue. March 30, 2016.

Kwok-Hung (Albert) Chung

Chung

Dr. Chung holds a Doctor of Dental Surgery degree (1979) from the National Defense Medical Center-Taiwan, a Doctor of Philosophy degree (1987) in Biomaterials from the Northwestern University at Chicago , and a certificate in Prosthodontics from the University of Texas, Health Science Center at San Antonio (2002).

Dr. Chung is a Professor of the Department of Restorative Dentistry. His current research focus remains on nano restorative materials used in clinical dentistry and the biomechanics of dental implants. He has authored numerous scientific and clinical articles in peer-reviewed journals.
Dr. Chung is a fellow of the Academy of Dental Materials and the International College for Dentists, a member of the International Association for Dental Research and the American College of Prosthodontists. He served as reviewer for many peer-reviewed journals. He is a frequent presenter at scientific meetings in and outside North America.

Dr. Chung’s personal interests include swimming, fishing, travel and classical music.

Frank Roberts

Interests

Regulation of inflammation in human adult periodontitis and other chronic inflammatory diseases, effects of chronic neutropenia on oral health, and biology and imaging of the dental implant.

Publications

  1. Schuler RF, Janakievski J, Hacker BM, O’Neal RB, Roberts FA.*  Effect of implant surface and grafting on implants placed into simulated extraction sockets: a histologic study in dogs.  Int J Oral Maxillofac Implants. 2010 Sep-Oct;25(5):893-900.
  2. Roberts FA, Hacker BM, Oswald TK, Mourad PD, McInnes C.  Evaluation of the use of ultrasound within a power toothbrush to dislodge oral bacteria using an in vitro Streptococcus mutans biofilm model.  Am J Dent. 2010 Apr;23(2):65-9.
  3. Mourad PD, Roberts FA, McInnes C.  Synergistic use of ultrasound and sonic motion for removal of dental plaque bacteria.  Compend Contin Educ Dent. 2007 Jul;28(7):354-8.
  4. Smith, J., Wong, C.S., Salamonik, E.B., Hacker, B.M., McDonald, R.A., Mancl, L.A., Williams, B.J., Ibrahim, A., and Roberts, F.A.* 2006  Sonic Tooth Brushing Reduces Gingival Overgrowth in Renal Transplant Recipients.  Pediatr. Nephr. Nov;21(11):1753-9.
  5. Cai, S., Fatherazi, S., Presland, R., Belton, C., Roberts, F.A., Goodwin, P., Schubert, M., and Izutsu, K. 2006. Evidence that TRPC1 Contributes to Calcium-Induced Differentiation of Human Keratinocytes. Pflugers Arch. Apr;452(1):43-52.
  6. Wang IC, Roberts FA.* 2005  Adjunctive Periodontal Therapies.  Pract. Proced. Aesthet. Dent. May;17(4):245-6.
  7. Hacker, B.M. and Roberts, F.A.* 2005.  Genetics of Periodontal Disease Pathogenesis.  Pract. Proced. Aesthet. Dent. 17(2):97-102 (cover article).

Zi-Jun Liu

Background

DDS in 1983, Nanjing Medical University, China, MS in Oral Physiology in 1986, The 4th Military Medical University, China, PhD in Oral Physiology in 1991, Osaka University, Japan.

Interests

Biology of craniofacial skeletons and musculatures (growth, remodeling, adaptation and biomechanics). Temporomandibular Joint (TMJ) function and functional disorders (TMD). Mechanism of orthodontic tooth movements and material properties of periodontal ligaments.

Publications

(*: Correspondence author, in chronological order)
Peer-Reviewed Papers

1. Liu Z.J.* and Wang H.Y.: A comparative study of sound patterns and arthrograms in the cases with TMJ disorders. J. Practical Stomatology, 2:36-40, 1986

2. Liu Z.J.*, Wang H.Y., Pu W.Y. and Yan C.Y.: EMG study on superior and inferior bellies of lateral pterygoid muscle in the normal adults and its clinical value. J. Practical Stomatology, 2:104-108, 1986

3. Liu Z.J.*, Wang H.Y. and Pu W.Y.: A comparative study on EMG of lateral pterygoid muscle and TMJ arthrography in the TMJ sounds patients. J. Practical Stomatology, 2:227-231, 1986

4. Wang H.Y., Shi J.Z., Yan C.Y. and Liu Z.J.: Properties of bite force in the normal adults. J. Practical Stomatology, 3:67-71, 1987

5. Liu Z.J.* and Wang H.Y.: TMJ disc displacement relative to condylar position and abnormality of mandibular movements. J. Comprehensive Stomatology, 3:136-139, 1987

6. Liu Z.J.* and Wang H.Y.: A clinical and radiological study in cases with TMJDS sounds. West China J. Stomatology, 5:239-243, 1987

7. Wang H.Y.*, Liu Z.J., Wang M.Q., Jiao G.L., Zhen Y.G. and Yang Z.G.: Design and application of 8-channel electromyograph used in oro-maxillofacial region. J. Practical Stomatology, 4:114-118, 1988.

8. Liu Z.J.* and Wang H.Y.: Comprehensive study on occlusion, EMG and radiography in cases with TMJ clickings. J. Chinese Stomatology, 23:276-278, 1988

9. Liu Z.J.*, Wang H.Y. and Pu W.Y.: Clinical and radiological observation on treatment of TMJ internal derangement by repositioning splint: A follow-up study by arthrography. J. Chinese Stomatology, 24:91-94, 1989

10. Liu Z.J.*, Wang H.Y. and Pu W.Y.: A comparative electromyographic study of the lateral pterygoid muscle and arthrography in patients with temporomandibular joint disturbance syndrome sounds. J. Prosthet Dent., 62:229-233, 1989

11. Gu G.M., Niu X.F., Ye X.Y., Li X.H. and Liu Z.J.*: A comparative study on mandibular position and electromyography of masticatory muscles in edentulous cases before and after complete denture prosthesis. J. Practical Stomatology, 6:111-114, 1990

12. Liu Z.J.*, Wang H.Y., Liu D.D. and Li G.P.: A computer-aid method of calculating TMJ space and its clinical application. J. Stomatology, 10:131-133, 1990

13. Liu Z.J.*: Coordination and modification of cortically induced rhythmic jaw and tongue movements in the rabbit. J. Osaka University Dental Society, 36:39-52, 1991

14. Xu R.S., Liu Z.J.*, Wang H.Y. and Yan C.Y.: Characteristics of condylar position and intercuspal position in the cases with Angle’s II and III malocclusion. West China J. Stomatology, 11:252-254, 1993

15. Liu Z.J.*, Wang H.Y., Masuda Y. and Morimoto T.: Cinefluororadiographic observation of cortically induced rhythmic movements of mandible, tongue and hyoid. West China J. Stomatology, 11:23-28, 1993

16. Liu Z.J., Masuda Y., Inoue T.*, Fuchihata M., Sumida A., Takata K. and Morimoto T.*: Coordination of cortically induced rhythmic jaw and tongue movements in the rabbit. J. Neurophysiol., 69:569-584, 1993

17. Liu Z.J.*, Wang H.Y., Masuda Y. and Morimoto T.: A comparative study between cortically induced fictive mastication and actual mastication in acute and chronic rabbits. J. Chinese Stomatology, 29:305-308, 1994.

18. Xu R.S.*, Liu Z.J., Wang H.Y., Lin Z. and He M.Y.: A study of the condyle position in Angle’s I, II, III malocclusion. China J. Orthodontics, 2:61-63, 1995

19. Tang W.Z., Tang L., Jin J. and Liu Z.J.*: Physiological properties of oral sensation. J. Practical Stomatology, 12:28-30, 1996

20. Yasui S., Nokubi T.*, Nakamura K., Nagashima T., Yoshida M., Yoyoshima M., Liu Z.J., Yao Y.L. and Wang H.Y.: Influences of the position of occlusal support on the perception of mandibular position. J. Japan Prosthodontic Society, 40:117-121, 1996

21. Liu Z.J.*, Kubata S., Yamagata Y., Suenaga S., Noikura T. and Ito G.: Quantitative and multidimensional evaluation of symptoms and correlative factors for temporomandibular disorders in clinical and subclinical subjects. J. Japan Orthodontic Society, 55:445-460, 1996

22. Liu Z.J.*, Ikeda K., Harada Y., Kasahara Y. and Ito G.: Functional properties of jaw and tongue muscles in rats fed a liquid diet after being weaned. J. Dent. Res., 77: 366-376, 1998

23. Liu Z.J.*, Yamagata Y., Kasahara Y. and Ito G.: Electromyographic examination of jaw muscles in relation to symptoms and occlusion of patients with temporomandibular joint disorders. J.Oral Rehabil., 26: 33-47,1999.

24. Ikeda K.*, Liu Z.J. and Ito G.: Development of alternative activity of masseter and anterior digastrics in rats fed by kneaded diet. Dentistry in Japan, 35: 81-83, 1999

25. Liu Z.J.* and Herring S.W.: Bone surface strains and internal bony pressures at the jaw joint during masticatory muscle contraction. Arch. Oral Biol., 45:95-112, 2000

26. Liu Z.J.*, Yamagata Y., Kuroe K., Suenaga S., Noikura K. and Ito G.: Morphological and positional assessments of TMJ components and lateral pterygoid muscle in relation to symptoms and occlusion of patients with temporomandibular disorders. J. Oral Rehabil., 27:860-874, 2000

27. Liu Z.J.* and Herring S.W.: Masticatory strains on osseous and ligamentous components of the jaw joint in miniature pigs. J. Orofac. Pain, 14:265-278, 2000

28. Herring S.W*. and Liu Z.J.: Loading of the TMJ: Anatomical and in vivo evidence from the bones Cells Tissues Organs, 169: 193-200, 2001

29. Herring S.W.*, Rafferty K.L., Liu Z.J. and Marshall C.D.: Jaw muscles and the skull in mammals: The biomechanics of mastication. J. Comp. Biochem. Physiol. 131:207-219, 2001

30. Sun Z.*, Liu Z.J. and Herring S.W.: Movement of TMJ tissue during mastication and passive manipulation: study in miniature pigs. Arch. Oral Biol., 47:293-305, 2002

31. Herring S.W.*, Decker J.D., Liu Z.J. and Ma T.: Temporomandibular joint in miniature pigs: Anatomy, cell replication, and relation to loading. Anat. Rec. 266:152-166, 2002

32. Connolly J.P.*, Liu Z.J, Wang L.L., Whelan M.F., Huang G.J., Williams J.K. and King G.J. A custom mandibular distraction device for the rat. J. Craniofac. Surg. 13:445-449, 2002

33. Gu G.M.*, Yoshida R., Liu Z.J., Hirose T. and Ito G.: Muscle fiber composition and electromyographic features of cervical muscles following prolonged head extension in growing rats. Eur. J. Orthod. 25:20-33, 2003

34. Liu Z.J.*, King G.J., Herring S.W. and Whelan M.F.: Alterations of morphology and microdensity in the Condyle following mandibular osteodistraction in the rat. J. Oral Maxillofac. Surg. 61:918-927, 2003

35. King G.J.*, Liu Z.J., Wang L.L., Chiu I.Y. Whelan M.F.and Huang G.J.: Effect of distraction rate and consolidation period on bone density in mandibular osteodistraction rats. Arch. Oral Biol. 48:299-308, 2003

36. Baskin C.R.*, Liu Z.J., King G.J. and Maggio-Price L.: Vascular leak syndrome in Sprague-Dawley rats in mandibular distraction osteogenesis study. Comp. Med. 53:207-212, 2003.

37. Liu Z. J.*, Green J.R., Moore C.A. and Herring S.W.: Time series analysis of jaw muscle contraction and tissue deformation during mastication in miniature pigs. J. Oral Rehabil. 31:7-17, 2004

38. Liu Z.J.*, Anderson M.W., Gu G.M. and King G.J.: Apoptosis in the regenerate produced by mandibular osteodistraction in skeleton mature rats. J. Orthod. Craniofac. Res. 8:41-51, 2005.

39. Liu Z.J.*, King, G.J. Gu G.M., Shin J.Y and D.R. Stewart.: Does human relaxin accelerate orthodontic tooth movement in rats? Ann NY Acad Sci 1041:388-394, 2005.

40. Shin J.Y., Liu Z.J.* and King G.J,: Trabecular organization of mandibular osteodistraction in growing and maturing rats. J. Oral Maxillofac. Surg. 63:77-86, 2005.

41. Williams B.E., King G. J., Liu Z.J.* and Rafferty K.L.: Dynamic histomorphometric analysis of regenerate osteogenesis following mandibular distraction in the rat. Arch. Oral Biol. 50:497-508, 2005.

42. Liu Z.J.*, King G.J and Herring S.W.: Condylar mineralization following mandibular distraction osteogenesis in rapidly and slowly growing rats. J. Dent. Res. 85: 653-657, 2006.

43. Okafuji N., Liu Z.J.* and King G.J.: Assessment of cell proliferation during mandibular osteodistraction in the mature rat. Am. J. Orthod. Dentofac. Orthop. 130:612-621, 2006.

44. Liu Z.J.*, Kayalioglu M., Shcherbatyy V. and Seifi A.: Tongue deformation, jaw movement and muscle activity during mastication in pigs. Arch. Oral Biol. 52:309-312, 2007.

45. Madan M.S., Liu Z.J.*, Gu G.M. and King G.J.: Effects of human relaxin on orthodontic tooth movement and periodontal ligaments in rats. Am. J. Orthod. Dentofac. Orthop. 131: 8e1-10, 2007.

46. Kayalioglu M., Shcherbatyy V. Seifi A. and Liu Z.J.*: Roles of tongue intrinsic and extrinsic muscles in feeding: Electromyographic study in pigs. Arch. Oral Biol. 52:786-796, 2007.

47. Ross C.F.*, Dharia R., Herring S.W., Hylander W.L., Liu Z.J., Rafferty K.L., Ravosa M.J. and Willaims S.H.: Modulation of mandibular corpus bone strain in mammals during mastication. J. Exp. Biol. 210:1046-63, 2007.

48. Shcherbatyy V. and Liu Z.J.*: Internal kinematics of the tongue during feeding in pigs. Anat. Rec. 290:128 1299, 2007.

49. Liu Z.J.*, Shcherbatyy V. and Perkins J.A.: Functional loads of the tongue and consequence of the volume reduction. J. Oral Maxillofac. Surg. 66(7):1351-1361, 2008,

50. Liu Z.J.*, Yamamura B., Shcherbatyy V. and Green J.R.: Regional volumetric changes of the tongue during mastication in pigs. J. Oral Rehabil. 35(8):604-612, 2008.

51. Shcherbatyy V., Perkins J.A. and Liu Z.J.*: Internal Kinematics of the Tongue following Volume Reduction. Anat. Rec. 291(7):886-893, 2008.

52. Liu Z.J.*, Shcherbatyy V, Gu G.M. and Perkins J.A.: Effects of tongue body volume reduction on craniofacial growth: A longitudinal study on orofacial skeletons and dental arches. Arch. Oral Biol. 53:991-1001, 2008.

53. Perkins J.A.*, Shcherbatyy V. and Liu Z.J.: Morphologic and histologic outcomes of tongue reduction surgery in an animal model. Otolaryngology-Head and Neck Surgery. 139:291-297, 2008.

54. Liu Z.J.*, Shcherbatyy V., Kayalioglu M. and Seifi A.: Internal kinematics of the tongue in relation to muscle activity and jaw movement during feeding. J. Oral. Rehabil. 36:660-674, 2009.

55. Yousefzadeh F., Shcherbatyy V., King G.J., Huang G.J. and Liu Z.J*: A cephalometric and electromyographic study in patients of East-African ethnicity with and without anterior open bite. Am. J. Orthod. Dentofac. Orthop. 137:236-246, 2010.

56. Ye W.M, Abu A.F and Liu Z.J*: Assessment of cell proliferation and muscular structure following surgical tongue volume reduction in pigs. Cell Proliferation, 43(6): 562-572, 2010.

57. Herring S.W., Rafferty K.L., Liu Z.J. and Lemme M.: Mastication and the postorbital ligament: Dynamic strain in soft tissues. Integrative & Comparative Biology, 51:297-306, 2011.

58. Rafferty K.L., Liu Z.J., Ye, M., Alfonso L.N., Nguyen T.T., Salamati A., Herrin S.W*: Botulinum toxin in masticatory muscles: Short- and long-term effects on muscle, bone, and craniofacial function in adult rabbits. Bone, 50(3):551-562, 2012.

59. Navarrete A.L., Rafferty KL, Liu Z.J., Ye W, Herring S.W.: Botulinum neurotoxin type A in the masseter muscle: Effects on incisor eruption in rabbits. Am. J. Orthod. Dentofac. Orthop. 143:499-506, 2013.

60. Ye W.M, Duan Y.Z. and Liu Z.J*: Alteration of functional loads after tongue volume reduction. J. Craniofac. Orthod Res, 16:234-245 2013.

Book Chapters

1. Liu Z.J.*, Wang H.Y., Masuda Y. and Morimoto T.: Coordination of jaw, tongue and hyoid muscles during drinking and mastication in the awake rabbit. In: Brain and Oral Function – Oral Motor Function and Dysfunction, T. Morimoto, T. Matsuya and K. Takada, Eds.,The Netherlands: Elsevier Science B.V., pp. 597-600, 1995

2. Morimoto T.*, Nakamura O., Ogata K., Liu Z.J., Matsuo R., Inoue T., Masuda Y., Saito O., Mizuno J. and Kato K.: Autoregulation of masticatory force in the anesthetized rabbit. In: Brain and Oral Function – Oral Motor Function and Dysfunction, T. Morimoto, T. Matsuya and K. Takata Eds., The Netherlands: Elsevier Science B.V., pp.115-124, 1995

3. Ikeda K.*, Liu Z.J., Harada S., Kasahara Y. and Ito G.: Alternative activities of masseter and anterior digastrics in growing rats fed a kneaded diet. In: Neurobiology of Mastication – from Molecular to System Approach, Y. Nakamura and B.J. Sessle, ed. The Netherlands: Elsevier Science B.V., pp. 379-381, 1999.

4. Herring S.W.*, Sun Z., Egbert M.A., Rafferty K.L. and Liu Z.J.: Is distraction the only motion permitted at the osteotomy site? Fixation and stability of the pig mandible. In: Biological Mechanisms of Tooth Movement & Craniofacial Adaptation, ed. Z. Davidovotch and J. Mah, Harvard Soc. Adv. Orthodontics, pp. 31-38, 2004.

5. Liu Z.J.*, King G.J. and Herring S.W.: Why do we fail to achieve predicted lengthening in mandibular osteodistraction? Observations on condylar morphology and microdensity in growing and maturing rats. In: Biological Mechanisms of Tooth Movement & Craniofacial Adaptation, ed. Z. Davidovitch and J. Mah, Harvard Soc. Adv. Orthodontics, pp. 39-51, 2004.

6. Liu Z.J.*, Shcherbatyy V., Kayalioglu M. and Seifi A.: Dimensional changes of the tongue during activation of hypoglossal nerves and contraction of tongue muscles. In: Biological Mechanisms of Tooth Eruption, Resorption, and Movement, ed. Z. Davidovitch and J. Mah, Harvard Soc. Adv. Orthodontics, pp. 305-312, 2006.

7. Pavlin D., Hulme R.D., King G.J., Liu Z.J., Gluhak-Heinrich J.: Regulation of osteopontin in para-surgical bone cell following mandibular distraction osteogenesis in rats. In: Biological Mechanisms of Tooth Eruption, Resorption, and Movement, ed. Z. Davidovitch and J. Mah, Harvard Soc. Adv. Orthodontics, pp. 429-438, 2006.

8. Herring S.W.*, Rafferty L.K, Liu Z.J. and Sun Z.: A non-primate model for the fused symphysis: in vivo studies in the pig. Vinyard, C.J., Ravosa, M.J., and C.E. Wall, eds. Primate Craniofacial Function and Biology; Series: Developments in Primatology Series. New York, Springer, 2008, p19-36.

9. Liu Z.J:* Effects of Surgical Tongue Volume Reduction: Outcome Measure on Function and Growth. In: Surgical Enhancement of Orthodontic Treatment. Monograph 47, Craniofacial Growth Series, ed. McNamara JA Jr, and Kapila SD. Department of Orthodontics and Pediatric Dentistry and Center for Human Growth and Development, The University of Michigan, Ann Arbor, pp. 283-308, 2010.

10. Herring S.W.*, Li Y.M., Liu Z.J., Popowics T.E., Rafferty K.L., and Wang S.L.: Oral Biology and Dental Models. In: The Minipigs in Biomedical Research. ed. PA. McAnulty, AD. Dayan, N-C. Ganderup, and KL. Hastings, CRC, Taylor & Francis Group, London, New York. p. 491-516, 2011.

11. Liu Z. J.: Tongue musculature – Response to neuromuscular diseases and specific pathologies. In: Craniofacial Muscles: A new Framework for Understanding the Effector Side of Craniofacial Muscle Control. Eds. LK Mcloon and F Andrate. Springer, New York, p. 241-262, 2013.

Greg J. Huang

Huang
Dr. Huang received his DMD 1987 University of Florida; MSD and Certificate in Orthodontics (1989) & MPH (2001) University of Washington. Diplomate of the American Board of Orthodontics. Associate Editor of AJODO. Private practice: Bellevue, WA.
Practice-based research, orthodontic outcomes and stability, evidence-based orthodontics.
  1. Huang GJ and Soderholm KJ. 1989. In vitro investigation of shear bond strength of a phosphate based dentinal bonding agent. Scand J Dent Res 97(1): 84-92.
  2. Huang GJ, Justus R, Kennedy DB, Kokich VG. 1990. Stability of anterior openbite treated with crib therapy. Angle Orthod 60(1): 17-24; discussion 25-6.
  3. Noxon SJ, King GJ, Gu G, Huang GJ. 2001. Osteoclast clearance from periodontal tissues during orthodontic tooth movement. AJODO 120(5): 466-76.
  4. Huang GJ, LeResche L, Critchlow CW, Martin MD, Drangsholt MT. 2002. Risk factors for diagnostic subgroups of painful TMD. JDR 81(4): 282-8.
  5. Connolly JP, Liu ZJ, Wang LL, Whelan MF, Huang GJ, Williams JK, King GJ. 2002. A custom mandibular distraction device for the rat. J Craniofac Surgery 13(3):445-52.
  6. Huang GJ. 2002. Long-term stability of anterior openbite therapy: a review. Seminars in Orthodontics 8(3): 132-72.
  7. Pang JWY, Heffelfinger JD, Huang GJ, Benedetti TJ, Weiss NS. 2002. Outcomes of planned home births in Washington state: 1989-1996. Obstet Gynecol 100(2): 253-9.
  8. King GJ, Wang LL, Liu ZJ, Chiu IY, Huang GJ. 2003. Effect of distraction rate and consolidation period on bone density following mandibular osteodistraction in rats. Archives of Oral Biology 48(4): 299-308.
  9. Huang GJ, del Aguila MA. 2003. The distribution of orthodontic services and fees in an insured population in Washington state. AJODO 124(4): 366-72.
  10. Bollen AM, Huang GJ, King GJ, Hujoel P, Ma T. 2003. Sequential removable orthodontic appliances, activation time and material stiffness – Part I: Ability to complete treatment. AJODO 124(5): 496-501
  11. Clements KM, Bollen AM, Huang GJ, King GJ, Hujoel P, Ma T. 2003. Sequential Removable Orthodontic Appliances, Activation Time and Material Stiffness – Part II: Dental Improvements. AJODO 124(5): 502-8.
  12. Huang GJ, Marston BE, del Aguila MA. 2004. Orthodontic care in an insured population in Washington: demographic factors. AJODO 125(6): 741-6.
  13. Nett BC, Huang GJ. 2005. Long-term posttreatment changes measured by the American Board of Orthodontics objective grading system. AJODO 127(4):444-50.
  14. Mirabelli JT, Huang GJ, Siu CH, King GJ, Omnell L. 2005. Effectiveness of phase I orthodontic treatment in a Medicaid population. AJODO 127(5):592-8.
  15. Ormiston JP, Huang GJ, Little RM, Decker JD, Seuk GD. 2005. A retrospective analysis of long-term stable and unstable orthodontic treatment outcomes. AJODO 128(5):568-74.
  16. Theis JE, Huang GJ. King GJ, Omnell ML. 2005. Eligibility for publicly funded orthodontic treatment determined by the handicapping labiolingual deviation index. AJODO 128(6):708-15.
  17. AAO Council on Scientific Affairs (Huang GJ, et al). 2005. Ask us: Functional appliances and long-term effects on mandibular growth. AJODO 128(3):271-2.
  18. Orsini GM, Huang GJ, Kiyak HA, Ramsay DS, Bollen AM, Anderson NK, Giddon DB. 2006. Innovative methods for evaluating facial profile preferences. AJODO 130(3):283-91.
  19. Huang GJ, Rue T. 2006. Third molar extraction as a risk factor for TMD. JADA 137(11)1547-54.
  20. LeResche L, Mancl LA, Drangsholt MT, Huang GJ, Von Korff M. 2007. Predictors of onset of facial pain and temporomandibular disorders in early adolescence. Pain 129(3):269-78. (Epub Nov 2006).
  21. Huang GJ, Drangsholt MA, Rue TC, Cruikshank DC, Hobson KA. 2008. Age and third molar extraction as risk factors for TMD. JDR 87(3):283-287.
  22. Kim S, Herring SW, Wang I-C, Alcalde R, Mak V, Fu IC, Huang GJ. 2008. A comparison of miniplates and teeth for orthodontic anchorage. AJODO 133(2):189.e1-9.
  23. Bollen AM, Cunha-Cruz J, Bakko DW, Huang GJ, Hujoel PP. 2008. Effects of orthodontic therapy on periodontal health; a systematic review of controlled evidence. JADA 139(4):413-22.
  24. Baldwin D, Bollen AM, King GJ, Ramsay DS, Huang GJ. 2008. Activation time and material stiffness of sequential removable orthodontic appliances. Part 3: Premolar extraction cases. AJODO 133:837-45.
  25. Hobson KA, Huang GJ, Covell DA. 2008. Patterns of dental care utilization among patients with TMD disorders. JOP 22:108-14.
  26. Marshall SD, English JD Jr, Huang GJ, Messersmith ML, Nah HD, Riolo ML, Shroff B, Southard TE, Suri L, Turpin DL. 2008. Ask us. Long-term stability of maxillary expansion. AJODO.133(6):780-1.
  27. Ryan-Taylor K, Kiyak A, Huang GJ, Greenlee GM, Jolley CJ, King GJ. 2009. Effects of Malocclusion and Its Treatment on the Quality of Life of Adolescents. AJODO 136:382-92.
  28. Suri L, Huang G, English JD Jr, Owen S, Nah HD, Riolo ML, Shroff B, Southard TE, Turpin DL. 2009. Ask us. Topical fluoride treatment. AJODO. 135(5):561-3.
  29. Struble BH and Huang GJ. 2010. A Comparison of Prospectively and Retrospectively Selected American Board of Orthodontics Cases. AJODO. 137(1): 6.e1-8; discussion 6-8.
  30. Yousefzadeh F, Shcherbatyy V, King GJ, Huang GJ, and Liu ZJ. 2010. A Cephalometric and Electromyographic Study of Open-bite/Overbite in Patients of East-African Ethnicity. AJODO. 137(2):236-46.
  31. Zuroff JP, Chen SH, Shapiro PA, Little RM, Joondeph DR, Huang GJ. 2010. Orthodontic Treatment of Anterior Open-bite Malocclusion: Stability Ten-years Post-retention. AJODO. 137(3):302.e1-8; discussion 302-3.
  32. Jolley C, Huang GJ, Greenlee GM, Spiekerman C, Kiyak HA King GK. 2010. The dental effects of interceptive treatment in a Medicaid population: results from a randomized clinical trial. AJODO.137(3):324-33.
  33. Chen SH, Greenlee GM, Kim E, Smith C, Huang GJ, 2010. A systematic review of self-ligating brackets. AJODO. 137(6): 726.e1-726.e18.
  34. Marshall SD, Currier FG, Hatch NE, Huang GJ, Nah HD, Owens SE, Shroff B, Southard TE, Suri L, Turpin DL. 2010. Ask Us: Self-ligating bracket claims. AJODO. 138(2):128-31.
  35. Hyde JD, King GJ, Greenlee GM, Spiekerman C, Huang GJ. 2010. Survey of orthodontist’s attitudes and experiences regarding miniscrew implants. JCO. 44: 481-6.
  36. Greenlee GM, Chen SH, Chen J, Huang GJ. 2011. Stability of treatment for anterior openbite malocclusion: a meta-analysis. AJODO 139(2):154-69.
  37. King GJ, Kiyak HA, Greenlee GM, Huang GJ, Spiekerman CF. 2012. Medicaid and privately financed orthodontic patients have similar occlusal and psychosocial outcomes. J Public Health Dent. 72:94-103.
  38. King GJ, Spiekerman CF, Greenlee GM, Huang GJ. 2012. Randomized clinical trial of interceptive and comprehensive orthodontics. J Dent Res. 91:59S-64S.
  39. Huang GJ, Bates S, Ehlert A, Whiting D, Chen S, Bollen AM. 2012. Stability of Deepbite Treatment: a systematic review. JWFO. 1:e89-96.
  40. Lotwala RB, Greenlee GM, Ott SM, Hall, SH, and Huang GJ. 2012. Bisphosphonates as a risk factor for adverse orthodontic outcomes: a retrospective cohort study. AJODO 142(5):625-634e3.
  41. Fontes AM, Joondeph DR, Bloomquist DS, Greenlee GM, Wallen TR, Huang GJ. 2012. Long-term stability of anterior open-bite closure with bilateral sagittal split osteotomy. AJODO 142(6):792-800.
  42. Huang GJ, Roloff-Chiang B, Bills BE, Shalchi S, Spiekerman C, Korpal AM, Starett JL, Greenlee GM, Drangsholt RJ, Matunas JC. 2013. The effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial. AJODO. 143:31-41.
  43. Senestraro SV, Crowe JJ, Wang M, Vo A, Huang G, Ferracane J, Covell DA Jr. 2013. Minimally invasive resin infiltration of arrested white-spot lesions: a randomized clinical trial. JADA. 144:997-1005.
  44. Cunha-Cruz J, Rothen M, Spiekerman C, Drangsholt M, McClellan L, Huang GJ. Recommendations for third molar removal: a practice-based cohort study. AJPH. (in press)
  45. Huang GJ, Cunha-Cruz J, Rothen M, Spiekerman C, Drangsholt M, Anderson L, Roset G. A prospective study of clinical outcomes related to third molar removal or retention. AJPH. (in press)
  1. Huang GJ, Gansky SA. 2001. The relationship between exogenous estrogen and TMD. J Evid Base Dent Pract 1:191-3.
  2. Huang GJ, Hujoel PP. 2002. The influence of age and sex on facial asymmetry. J Evid Base Dent Pract 2: 80-1.
  3. Huang GJ. 2002. Effect of combined antimicrobial and fluoride varnish in orthodontic patients. J Evid Base Dent Pract 2:115-6.
  4. John MT, Huang GJ. 2002. The psychosocial impact of orthognathic surgery is unknown. J Evid Base Dent Pract 2: 211.
  5. Huang, GJ. 2003. Traditional orthodontic treatment, orthodontic appliances, and extraction for orthodontic treatment do not appear to cause TMD. J Evid Base Dent Pract 3:28-30.
  6. Huang GJ. 2003. Case Report – How would you treat this malocclusion? PCSO Bulletin 75(3): 24-25, 46-47.
  7. Huang GJ. 2004. The effectiveness of the twin-block appliance for the correction of class II division I malocclusion during mixed dentition. J Evid Base Dent Pract 4:222-3.
  8. Huang GJ. 2004. The psychosocial benefits of the twin-block appliance in class II division I patients during mixed dentition. J Evid Base Dent Pract 4:286-7.
  9. Huang GJ. 2004. Making the case for evidence-based orthodontics . AJODO 125(4): 405-6.
  10. Huang GJ. 2004. Occlusal adjustment for treating and preventing temporomandibular disorders. AJODO 126(2):138-9.
  11. Huang GJ. 2005. Orthodontic repositioning of traumatically intruded maxillary incisors minimizes negative sequelae. J Evid Base Dent Pract 5:145-6.
  12. Huang GJ. 2005. Fasten you seat belts for the bumpy ride to evidence-based practice. AJODO 127(1):4-5.
  13. Huang GJ. 2005. What do we want to know? AJODO 127(6):648-9.
  14. Huang GJ. 2006. Bigfoot lives? AJODO 129(3):323-4.
  15. Huang GJ. 2006. Accessing evidence via the internet. AJODO 130(2):129-30.
  16. Huang GJ. 2007 Early mandibular first molar removal because of caries facilitates eruption of the ipsilateral third molar. J Evid Base Dent Pract 7:25-6.
  17. Huang GJ. 2007. AGD master’s level dentists provide little or no orthodontic care. J Evid Base Dent Pract 7:88-9.
  18. Huang GJ. 2007. Things that make me nervous. AJODO 131(5):579-80. (reprinted as a guest editorial in the Washington Stated Dental Association News. 2007, 54(10):5-7, and in the Delaware Dental Association Newsletter, Sept/Oct 2007.)
  19. Huang GJ. 2008. Posterior unilateral crossbite does not appear to be a risk factor for TMJ clicking in young adolescents. J Evid Base Dent Pract 8:43-4.
  20. Huang GJ.2008. Fourth and forty? Am J Orthod Dentofacial Orthop 134(2):174-5.
  21. Huang GJ. 2009. Insufficient evidence to conclude that orthodontic patients derive benefits from using power toothbrushes. JADA 140(7): 914-5.
  22. Thurman MM and Huang GJ. 2009. Insufficient evidence to support the use of stabilization splints over other active interventions in the treatment of temporomandibular myofascial pain. JADA 140(12): 1524-5.
  23. DaBell J and Huang GJ. 2010. Evidence indicates minimal short-term space loss after premature loss of primary first molars. JADA 141(1): 77-8.
  1. Orthodontics: current principles and techniques, 5th Edition. Graber, Vanarsdall, and Vig. Chapter 29: searching for the evidence for practice. (June, 2011)
  2. Evidence-based orthodontics. Huang, Richmond, and Vig, editors (May, 2011)
  3. Evidence-based orthodontics. Huang, Richmond, and Vig, editors. Chapter on Open-bite (May, 2011)
  4. Seminars in Orthodontics (Evidence-based Orthodontics issue). 2013:19(3). Vig and Huang, guest editors.