Blood, Autoimmune & Neoplasia
Course Director: David Dean
Quarters/Yr of Program: Winter / 1
This overview of hematology and oncology addresses the biology of bone marrow and blood and introduces the multidisciplinary field of cancer medicine. Specific cancer subtypes provide illustrative examples of the impact of molecular biology and environmental risk factors on the development and treatment of malignancy. There will be an emphasis on head and neck cancer and the oral complications of cancer therapy.
The student who successfully completes this course will be able to:
1. Differentiate the properties of hematopoietic stem cells and mature blood cells.
2. Outline the process of hematopoiesis from hematopoietic stem cell through terminal differentiation in the lymphoid and myeloid lineages.
3. Compare and contrast the morphology, function, and relative life span of erythrocytes, granulocytes, lymphocytes, and thrombocytes.
4. Summarize the clinical features of anemia, neutropenia, thrombocytopenia, aplastic anemia, thalassemia, and sickle cell anemia and the diagnostic tests in their assessment.
5. Describe the functional components of the immune system and the clinical impacts of immunosuppression.
6. Explain the clinical significance of each item in a CBC with differential.
7. Rank the relative proportion of white blood cell subtypes under normal circumstances.
8. Create a perioperative treatment plan for a patient with anemia.
9. Explain the goals of chemotherapy, radiation therapy, head-and-neck cancer surgery, hematopoietic cell transplantation, and anti-osteoclastic therapy in the treatment of cancer.
10. Create a perioperative treatment plan for a patient with neutropenia.
11. Outline the steps in hemostasis.
12. Summarize the clinical features of abnormal hemostasis and thrombosis.
13. Create a perioperative plan for a patient with elevated risk for bleeding.
14. Compare and contrast the characteristics of normal cells with those in benign neoplasia, malignancy, and metastasis.
15. Describe the histologic features of normal epithelium, benign epithelial hyperplasia, epithelial dysplasia, carcinoma in situ, and squamous cell carcinoma.
16. Summarize the modifiable and non-modifiable factors influencing cancer risk (including risk factors for oral and oropharyngeal cancer).
17. Describe the clinical characteristics of the most common solid cancers in the United States and the screening tools used to identify them.
18. Explain the functional purpose of cancer chemotherapy and the biological principles on which chemotherapies are based.
19. Describe the clinical characteristics and relative potential for malignant transformation for leukoplakia, erythroplakia, proliferative verrucous leukoplakia, and oral lichen planus.
20. Compare the epidemiologic, pathophysiologic, and clinical characteristics of tobacco-induced oral squamous cell carcinoma and HPV-induced oropharyngeal squamous cell carcinoma.
21. Identify signs and symptoms suspicious for cancer based on patient history and clinical examination.
22. Design a diagnostic plan when signs or symptoms suspicious for cancer are identified.
23. Compare and contrast treatment modalities for oral and oropharyngeal squamous cell carcinoma based on TNM staging and depth of invasion.
24. Describe the anticipated treatment course, adverse effects, and potential oral complications of chemotherapy, radiation therapy, head-and-neck cancer surgery, hematopoietic cell transplantation, and anti-osteoclastic therapy in the treatment of cancer.
25. Create a treatment plan to minimize, mitigate, or manage the potential oral complications of chemotherapy, radiation therapy, head-and-neck cancer surgery, hematopoietic cell transplantation, and anti-osteoclastic therapy.
UWSOD Competencies: C-01, C-03, C-10, C-12, C-13, C-14, C-15, C-17, C-18, C-24, C-28, C-31, CE-02, CE-03, CE-06
Date last updated: 2022-03-30