Dental Curriculum Threads

Molecular and Cellular Basis of Disease

Course Director: Whasun “Sun” Oh Chung
Credits: 6
Quarters/Yr of Program: Autumn / 1

Course Overview

This course covers a broad range of topics in molecular and cellular biology, including cell basics, enzymes, protein/carbohydrate/lipid metabolism, cancer, neurobiology, pharmacology, and histology. Students will learn how various diseases are caused by and regulated at molecular and cellular levels. The first part of each day will mostly be devoted to reviewing previously assigned reading materials, followed by discussions of appropriate case-based studies in a small group format. Successful completion of this course will help prepare students to assess what cellular changes are responsible for and how to intervene diseases that are of importance in dentistry.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the “central dogma” of molecular biology: the informational roles of DNA, RNA, and protein.
2. Explain the regulation and the effects of carbohydrate, protein, and lipid metabolism.
3. Explain the functions of DNA methylation, covalent histone modifications, and non-coding RNAs in producing epigenetic effects; predict the outcomes of specific epigenetic changes on gene expression.
4. Describe how defects in DNA repair pathways lead to specific syndromes.
5. Describe the hallmarks of cancer and their pathophysiology.
6. Compare drug/receptor interactions and dose/response/therapeutic window.
7. Recognize and describe the histological types, structural characteristics, and functions of epithelia.
8. Define the anatomic (central and peripheral) and functional (somatic and autonomic) divisions of the nervous system.
9. Describe the processes of cell injury, inflammation, and repair.

UWSOD Competencies: 1, 2, 3, 4, 7, 12

Date last updated: 2018-10-04