Molecular and Cellular Basis of Disease
Course Director: Whasun “Sun” Oh Chung
Credits: 4
Quarters/Yr of Program: Autumn / 1
Course Overview
This course covers a broad range of topics in molecular and cellular biology, including cell basics, enzymes, protein/carbohydrate/lipid metabolism, and cancer. Students will learn how various diseases are caused and regulated at molecular and cellular levels. Successful completion of this course will help students assess what cellular changes are responsible for diseases and how to intervene in diseases that are of importance in dentistry.
Learning Objectives
The student who successfully completes this course will be able to do the following:
1. Describe the central dogma of molecular biology in the context of the roles DNA, RNA, and protein play in disease development.
2. Illustrate how carbohydrate, protein, and lipid metabolisms lead to certain physiological outcomes.
3. Explain how DNA methylation, covalent histone modifications, and non-coding RNAs alter specific epigenetic changes on gene expression.
4. Differentiate how defects in DNA repair pathways lead to specific syndromes and are remedied.
5. Assess the aspects of cancer pathophysiology from disease onset to projected outcomes.
6. Analyze how homeostasis in health and disease is affected by the inflammation and repair processes.
UWSOD Competencies: CE-02, CE-03, C-03, CE-06, C-08, C-15, C-14, C-12, C-13, C-31, C-11, C-30, C-24, C-25, C-26, C-23
Date last updated: 2024-09-23