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UW School of Dentistry

DENTFN 502

Dental Curriculum Threads

Introduction to Biomedical Foundations

Course Director: Elizabeth Garcia
Credits: 2
Quarters/Yr of Program: Summer / 1

Course Overview

Introduction to Biomedical Foundations is a general survey course covering the fundamentals of anatomy, histology, pharmacology, and cellular communication in the human. The information will prepare the student for the required rigorous 18-month collective of courses called Biomedical Foundations.

Learning Objectives

The student who successfully completes this course will be able to:

  1. Explain fundamental concepts of human cellular communication.
  2. Explain general principles of the ligand/receptor complex.
  3. Explain general concepts of action potentials.
  4. Explain fundamental concepts of the study of human structures on a microscopic level (histology).
  5. Identify major human structures by their microscopic appearance.
  6. Explain how the microscopically identified structures will typically function in the human body.
  7. Explain fundamental concepts of pharmacology.
  8. Discuss major pharmacologic principles of human medicine.
  9. Explain fundamental concepts of human anatomy.
  10. Identify major anatomical structures in the human.
  11. Initiate the development of presentation skills used in clinical health care.

UWSOD Competencies: C-03, C-17, CE-02, CE-03, CE-06

Date last updated: 2023-07-05

DENTFN 532

Dental Curriculum Threads

Renal & Respiratory

Course Director: Bruce Silverstein
Credits: 4
Quarters/Yr of Program: Spring / 1

Course Overview

This course will give students an integrated understanding of the respiratory and renal systems of the body. Students will follow how oxygen and nutrients move from the environment to the tissues, and how waste products of metabolism follow the opposite path, examining the coordinated roles of the lungs and kidneys in the control and regulation of these processes and the maintenance of homeostasis. Students will consider physiology and disease processes at the level of the organ system, with a focus on the physiology and pathophysiology of the lungs and kidneys. Understanding these systems is key to understanding human health and disease for the practice of general dentistry.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the external and internal morphology of the kidneys and lungs.
2. Use anatomical specimens, medical imaging, and living adults to explain key anatomical relationships between the kidneys, lungs, major blood vessels, and the structures and landmarks that surround them.
3. Describe the normal physiology of the renal and respiratory systems.
4. Delineate the role of the renal and respiratory systems in maintaining homeostasis including sodium and water regulation, electrolyte balance, and acid-base balance.
5. Identify connections between pathophysiologic and histopathologic abnormalities and the major disease processes affecting the kidneys and lungs.
6. Interpret clinical, laboratory, radiographic, and histopathologic data to identify the major disease processes affecting the renal and respiratory systems.
7. Identify the etiology, epidemiology, pathogenesis, clinical features, diagnostic features, prevention, treatment, and prognosis of major diseases and conditions of the pulmonary and renal systems, including implications for the practice of dental medicine.
8. Outline a treatment approach, including pharmacologic and non-pharmacologic measures, for the major disease processes affecting the lungs and kidneys.
9. Relate the mechanism of action for major classes of drugs to the pathophysiology of the major diseases of the kidneys and lungs.
10. Interpret clinical and other diagnostic information, recognizing the side effects and primary toxicities of the major classes of drugs used to treat diseases of the kidneys and lungs.
11. Describe how pulmonary and renal diseases affect the oral cavity and the provision of dental care.

UWSOD Competencies: C-01, C-03, C-10, C-11, C-12, C-13, C-14, C-17, C-28, C-31, CE-02, CE-03, CE-06

Date last updated: 2022-03-20

DENTFN 561

Dental Curriculum Threads

Lifecycle

Course Director: Elizabeth Garcia
Credits: 4
Quarters/Yr of Program: Autumn / 2

Course Overview

This course covers biomedical foundational information about the human lifespan from conception until death. Students will learn biological processes governing normal human development, reproduction, and aging, as well as common disease processes and pathology. Dental practice relevancy will be emphasized when applicable.

Learning Objectives

The student who successfully completes this course will be able to:

1. Summarize the physiologic changes that occur with pregnancy.
2. Compare general physiology principles, common pathologies, and common pharmacologic interventions to the physiological changes of pregnancy.
3. Identify the normal anatomy and physiology of the reproductive systems.
4. Generate an overview of the complex hormonal and anatomical systems which allow for human reproduction.
5. Create an overview of human reproduction from gamete to embryo, as well as an overview of the pregnancy process.
6. Characterize normal embryonic, fetal, and childhood growth and development as well as reproductive maturity, aging, and end-of-life processes and common deviations that can occur in this typical lifecycle.
7. Discuss common pathologies of the reproductive systems.
8. Describe the natural processes of aging, death, and dying, from the health practitioners’ viewpoint.
9. Reflect on the relationship of dental management within the arc of the human lifecycle.

UWSOD Competencies: C-01, C-02, C-03, C-04, C-05, C-09, C-10, C-11, C-12, C-13, C-14, C-15, C-17, C-31, CE-02, CE-03, CE-06

Date last updated: 2022-11-08

DENTFN 560

Dental Curriculum Threads

Mind, Brain, and Behavior

Course Director: Fritzie Arce-McShane & Malveeka Sharma
Credits: 5
Quarters/Yr of Program: Autumn / 2

Course Overview

Students will study the structure and function of the human nervous system and its observable behavior ranging from reflexes to sensorimotor, cognitive, and social behavior. Learning is integrated in lectures, small groups, laboratory settings, and directed self-learning formats.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the structure, function, and physiology of the nervous system.2. Classify the criteria for psychiatric diagnoses as defined in DSM-V in discussions of clinical dental care.3. Apply pathophysiological mechanisms, clinical findings, risk factors, and differential diagnoses of neurological diseases and disorders to discussions of clinical dental care.4. Describe the major pathologies of the central and peripheral nervous systems.

UWSOD Competencies: C-01, C-03, C-04, C-05, C-10, C-11, C-12, C-13, C-14, C-15, C-17, C-18, C-29, C-30, C-31, CE-02, CE-03, CE-06

Date last updated: 2023-09-19

DENTFN 531

Dental Curriculum Threads

Gastrointestinal & Endocrine

Course Director: Bruce Silverstein
Credits: 5
Quarters/Yr of Program: Spring / 1

Course Overview

This lecture course provides a comprehensive overview of the gastrointestinal (including the liver) and endocrine systems. Understanding these systems is key to understanding human health and disease for the practice of general dentistry. Students explore relevant anatomy, histology, pathophysiology, and pharmacology. They learn how energy metabolism, nutrition, obesity, and diabetes fit into these systems.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the normal physiologic functions of the major endocrine and gastrointestinal organs.
2. Describe the hormonal feedback mechanisms of the endocrine and gastrointestinal systems that result in normal function.
3. Relate altered hormonal feedback mechanisms to disease processes in the endocrine and gastrointestinal systems.
4. Describe the pathologic processes that lead to disease in the endocrine and gastrointestinal organ systems.
5. Describe the etiology of the major diseases that affect the gastrointestinal tract, the liver, and the endocrine system.
6. Describe the clinical manifestations of the major diseases that affect the gastrointestinal tract, the liver, and the endocrine system and their oral components.
7. Relate knowledge of the cellular structures of the tissues and organs to their normal function in the endocrine and gastrointestinal systems.

UWSOD Competencies: C-01, C-03, C-10, C-11, C-17, C-18, C-26, C-28, C-31, CE-02, CE-03, CE-06

Date last updated: 2023-03-20

 

DENTFN 530

Dental Curriculum Threads

Blood, Autoimmune & Neoplasia

Course Director: David Dean
Credits: 4
Quarters/Yr of Program: Winter / 1

Course Overview

This overview of hematology, oncology, and autoimmunity addresses the biology of bone marrow, blood, and immune system while introducing the multidisciplinary fields of rheumatology and cancer medicine. Emphasis is on oral manifestations of autoimmune diseases, head-and-neck cancers, and the oral complications of cancer therapy.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the development, physiologic features, and clinical significance of all blood cell lineages.
2. Provide preoperative medical assessment and perioperative dental treatment plans for patients with benign and malignant hematologic disorders.
3. Describe the physiologic features and clinical significance of the innate and adaptive immune systems.
4. Describe the epidemiology, clinical characteristics, and expected natural history of common immune-mediated systemic disorders
5. Provide preoperative medical assessment and perioperative dental treatment plans for patients with systemic autoimmune disorders.
6. Outline the physiologic steps in hemostasis and the clinical implications of altered hemostasis.
7. Provide preoperative medical assessment and perioperative dental treatment plans for patients with hemostatic and thrombotic disorders.
8. Describe the physiologic features, clinical manifestations, and impacts of cancer and cancer therapy.
9. Provide diagnostic assessment and perioperative dental treatment plans for patients with known or suspected oral premalignant lesions, oral cancer, and oropharyngeal cancer.

UWSOD Competencies: C-01, C-03, C-10, C-12, C-13, C-14, C-15, C-17, C-18, C-24, C-25, C-28, C-31, CE-02, CE-03, CE-06

Date last updated: 2023-01-02

DENTFN 520

Dental Curriculum Threads

Cardiovascular

Course Director: Bruce Silverstein
Credits: 4
Quarters/Yr of Program: Winter / 1

Course Overview

This course will give students an integrated knowledge of the body’s circulatory system. They will study the complete cardiovascular system with a focus on the physiology and pathophysiology of disease states. A firm foundation in this system is key to recognizing the synergy of human health and disease with the practice of general dentistry.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the external and internal morphology of the heart and the aorta and its major branch vessels.
2. Use anatomical specimens, medical imaging, and living adults to explain key anatomical relationships between the heart and major blood vessels, and the structures and landmarks that surround them.
3. Describe the normal physiology of the cardiovascular system.
4. Identify connections between pathophysiologic and histopathologic abnormalities and the major disease processes affecting the heart and vascular system.
5. Interpret clinical, laboratory, radiographic, and histopathologic data to identify the major disease processes affecting the cardiovascular system.
6. Identify the etiology, epidemiology, pathogenesis, clinical features, diagnostic features, prevention, treatment and prognosis of major diseases and conditions of the cardiac systems, including implications for the practice of dental medicine.
7. Outline a treatment approach, including pharmacologic and non-pharmacologic measures, for the major disease processes affecting the heart and vascular system.
8. Relate the mechanism of action for major classes of drugs to the pathophysiology of the major diseases of the heart and blood vessels.
9. Interpret clinical and other diagnostic information, recognizing the side effects and primary toxicities of the major classes of drugs used to treat diseases of the heart and blood vessels.
10. Recognize a cardiac emergency in a dental patient.
11. Describe how cardiac diseases affect the oral cavity and the provision of dental care.

UWSOD Competencies: C-01, C-03, C-09, C-10, C-11, C-12, C-13, C-14, C-17, C-28, C-31, CE-02, CE-03, CE-06, CE-07

Date last updated: 2023-01-02

DENTFN 511

Dental Curriculum Threads

Invaders and Defenders

Course Director: Whasun “Sun” Oh Chung
Credits: 5
Quarters/Yr of Program: Autumn/ 1

Course Overview

Students will analyze critical concepts of microbiology and immunology, in both health and disease, using content-specific language. By the completion of this course, they will be able to interpret the manifestations of host-immune and pathogen responses in common infections of global health that impact dentistry. Classes will include large group lectures and small group discussions of case-based studies.

Learning Objectives

The student who successfully completes this course will be able to:

1. Analyze common diagnostic results of infectious and immune-mediated diseases.
2. Analyze factors that contribute to the expanding impact of infectious diseases on interdependent health communities locally and globally.
3. Apply evidence-based approaches to the management and prevention of infectious and immune-mediated diseases.
4. Describe the characteristics of antimicrobials, their mechanisms of action, mechanisms of resistance, and adverse effects including allergy.
5. Compare normal innate and adaptive immune mechanisms used to recognize, control, and clear pathogens.
6. Apply the clinical features, cells, and soluble mediators of inflammation to an explanation of beneficial and deleterious inflammatory responses.
7. Compare normal and abnormal immune mechanisms that mediate tolerance, autoimmunity, and allergy.
8. Relate the macroscopic and microscopic anatomy of the lymphoid system to how cells and proteins of the immune system traffic and interact in the lymphoid system to generate an immune response.

UWSOD Competencies: C-01, C-03, C-08, C-11, C-12, C-15, C-17, C-24, C-30, C-31

Date last updated: 2022-02-11

DENTFN 510

Dental Curriculum Threads

Molecular and Cellular Basis of Disease

Course Director: Whasun “Sun” Oh Chung
Credits: 4
Quarters/Yr of Program: Autumn / 1

Course Overview

This course covers a broad range of topics in molecular and cellular biology, including cell basics, enzymes, protein/carbohydrate/lipid metabolism, and cancer. Students will learn how various diseases are caused and regulated at molecular and cellular levels. Successful completion of this course will help students assess what cellular changes are responsible for diseases and how to intervene in diseases that are of importance in dentistry.

Learning Objectives

The student who successfully completes this course will be able to:

1. Describe the central dogma of molecular biology and the informational roles DNA, RNA, and protein play in disease development.
2. Illustrate carbohydrate, protein, and lipid metabolism, and how each metabolic regulation leads to certain physiological outcomes.
3. Explain the functions of DNA methylation, covalent histone modifications, and non-coding RNAs in producing epigenetic effects and outcomes of specific epigenetic changes on gene expression.
4. Differentiate how defects in DNA repair pathways lead to specific syndromes and how these defects could be remedied.
5. Assess aspects of cancer pathophysiology and how each leads to a projected outcome.
6. Analyze the cell injury, inflammation, and repair processes and how each contributes to homeostasis in health and disease.

UWSOD Competencies: C-03, C-08, C-11, C-12, C-13, C-14, C-15, C-23, C-24, C-25, C-26, C-30, C-31, CE-02, CE-03, CE-06

Date last updated: 2023-09-07