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Continuing Dental Education

To Extract or Not to Extract in Post-Irradiated Oral and Oropharyngeal Cancer Patients in the era of Pentoxifylline and Tocopherol – a live webinar

Adepitan A. Owosho, DDS, FAAOM, DABOMP

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This course is part of the Association for Continuing Dental Education Joint Live Webinar Series.


This course is part of the Association for Continuing Dental Education Joint Live Webinar Series*

Course Description

Approximately 50,000 individuals are newly diagnosed with oral and pharyngeal cancer every year in the United States. Most patients are diagnosed at a later stage thereby warranting the use of radiotherapy either as neoadjuvant or adjuvant therapy. Even with advance radiation delivery techniques such as intensity-modulated radiation therapy and intensity-modulated proton therapy, oral complications such as xerostomia, caries, trismus, and osteoradionecrosis (ORN) still exist. Post-radiation patients to the oral and oropharynx cavity are prone to developing rampant dental caries that may result in dental extractions.

ORN is the most morbid oral complication of radiotherapy that may be managed with segmental jaw resection and reconstruction with bone flap/graft. The risk of osteoradionecrosis post-extraction in an irradiated oral/pharynx cavity is for life. Prevention of ORN in these patients is crucial. This lecture will focus on the use of pentoxifylline-tocopherol in preventing ORN in post-radiation patients that require dental extractions.

Course Objectives

As a result of attending this course you should be able to:

  • Understand the etiology, risk factors, pathophysiology, and management of ORN.
  • Understand the pharmacologic properties of pentoxifylline and tocopherol.
  • Prophylactic use of pentoxifylline and tocopherol for preventing ORN in post-irradiated patient requiring dental extractions.


Dr. Adepitan A. OwoshoAdepitan A. Owosho obtained is dental degree from Obafemi Awolowo University, Nigeria after which he practiced dentistry for 2 years. He completed a 3-year residency training in Oral and Maxillofacial Pathology at the University of Pittsburgh Medical Center in Pennsylvania. Subsequently, he completed a 2-year Oral/Dental Oncology clinical research fellowship at Memorial Sloan Kettering Cancer Center in New York. After his fellowship training he joined the faculty of the College of Dental Medicine, University of New England, Maine as an Assistant Clinical Professor of oral and maxillofacial pathology and oral medicine. In 2019, he joined the Missouri School of Dentistry and Oral Health, A.T. Still University as an Associate Professor and Director of Integrated Human Sciences. In August 2022, Dr. Owosho joined The University of Tennessee Health Sciences Center, College of Dentistry, Department of Diagnostic Sciences as an Associate Professor.

Dr. Owosho’s clinical and research interest lies in the prevention and management of oral complications in oncology patients, immunophenotypic and molecular studies of odontogenic tumors, and bone and soft tissue tumors. He has co-authored several manuscripts on these topics in reputable peer-reviewed journals of Pathology and Dentistry and was the recipient of the 2018 H. Dean Millard award for the best publication in the oral medicine Section of Elsevier’s Oral Surgery Oral Medicine Oral Pathology Oral Radiology Journal by the American Academy of Oral Medicine.
Dr. Owosho serves on the academic fellowship committee as a fellowship examiner for the American Academy of Oral Medicine.


  • Dr. Williams has no relevant financial relationships to disclose.
  • The staff of the University of Washington Office of Continuing Dental Education have no relevant financial relationships to disclose.

Course Logistics

Friday, April 5, 2024

Online Webinar

The dental professional

8:00am – 9:00am Pacific Standard time


1 hour


*The University of Washington in conjunction with the Association for Continuing Dental Education (ACDE), along with 35 of its member schools jointly presents the “ACDE Webinar Series”

This series features university-based key opinion leaders presenting numerous topics on multiple dates and times. Presentations are available to meet every dental health care professional’s schedule and interests.

Conflict of Interest
In accordance with the ADA CERP Standard V., everyone involved in planning or presenting this educational activity will be required to disclose any relevant financial relationships with commercial interests and this information will be made available to participants at the start of the course.

As a continuing education provider, University of Washington Continuing Dental Education is responsible for ensuring the content, quality and scientific integrity of all continuing dental education activities for which credit is provided. The School is also responsible for taking steps to protect against and/or disclose any conflict of interest of the faculty/instructors presenting those courses.

Cancellation and Refunds
For this live webinar, a registration refund will be issued for cancellations received by Thursday, April 4, 2024. Registration will remain open until the webinar begins – NO REFUNDS will be accepted once the webinar has begun. Cancellations must be received in email to The cancellation request must include: the name of the course, name of the person registered, name of the person requesting the cancellation, and the reason for the cancellation.

By providing my information, I consent to receive communication via mail, email, fax, and phone from the University of Washington Continuing Dental Education office. The Continuing Dental Education office will not share your information with anyone.

Dental education institutions have an obligation to disseminate new knowledge related to dental practice. In so doing, some presentations may include controversial materials or commercial references. Sponsorship of a continuing education course by the University of Washington does not necessarily imply endorsement of a particular philosophy, procedure, or product by this institution.

The University of Washington Continuing Dental Education cautions continuing dental education participants that there are potential risks of using limited knowledge when incorporating new techniques and procedures into the practice of dentistry, especially when the continuing education course has not provided supervised clinical experience and/or competency tests in the techniques or procedures.

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University of Washington
Continuing Dental Education
Box 357137
Seattle, WA 98195-7137

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The University of Washington is an ADA CERP Recognized Provider.
ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.

This continuing education activity has been planned and implemented in accordance with the standards of the ADA Continuing Education Recognition Program (ADA CERP) through joint efforts between the University of Washington and ACDE member schools.

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The University of Washington is a member of the Association for Continuing Dental Education.

University of Washington designates this activity for 1 continuing education credit.