PhD

Program Description

The Oral Biology PhD program usually requires five years.  Students are expected to devote the full twelve-month year to their graduate work (allowing time for vacation and holidays).  Graduate students will have the opportunity to assist in the teaching program of the department as a practical means of gaining experience in the presentation of lectures and laboratory work.

Courses Requirements

The course requirement is a minimum of 90 credits (including at least 27 credits of thesis).  Through their coursework, students are expected to gain proficiency in one or more basic biologic sciences and to master modern biological approaches in addition to gaining expertise in the subject area of oral and craniofacial sciences.  At least 15 credit hours must come from science courses in departments other than Oral Biology.  These will include courses offered through the Molecular and Cell Biology Program and courses selected to match the basic science interests of the student.  Cross-disciplinary training in Bioengineering is also available.  All graduate students are also expected to attend and participate in departmental seminars (ORALB 575).

Following is an approximate timeline for completion of the PhD degree.  Because each student’s program and research goals will vary, completion of the requirements for the PhD degree may not necessarily follow this timeline.

Oral Biology Pathway

 

Year 1

Initial Course Work. All new students meet with the Graduate Program Coordinator before the start of classes in the Autumn Quarter to consider the student’s course work.  The selection of courses will depend on the student’s background, research goals, and interests.

Research Rotation. During each quarter of the first year of graduate study, the student will register for ORALB 578, Research Techniques.  The purpose of this course is for students to carry out research projects in the laboratories of several faculty members in order to prepare for the choice of their PhD project mentor and to learn a variety of research methods.  Each student is expected to take 2-3 rotations in different laboratories and select a research mentor by the end of the 1st year.

Year 2

Course Work. Students will continue to take courses that will include the remainder of the core courses required in Oral Biology and courses in other disciplines relevant to the student’s dissertation research.

Teaching.  Students are encouraged to take elective courses offered through the Medical Education and Graduate School which will help them in their future teaching careers.  Also, beginning in the second year, graduate students will have the opportunity to take part in teaching one of the Department courses for undergraduate dental students.  This experience prepares students for teaching responsibilities after receipt of the PhD and provides a good opportunity for consolidation of the student’s general oral biology background.

Research.. Early in the second year of study, the student is expected to choose a thesis adviser and to define a dissertation problem.

The Supervisory Committee. Once a thesis mentor and research direction have been chosen, the student and mentor will select a Supervisory Committee.  This should be done in year two or by the third year at the latest.  The committee is composed of at least four faculty members, at least three of whom (Including the Chair and the Graduate School Representative) must be members of the Graduate Faculty with an endorsement to chair doctoral committees.  The Graduate Program Coordinator will forward the list of recommended committee members to the Dean of the Graduate School who will officially appoint the Supervisory Committee.  In accordance with Graduate School regulations, the Supervisory Committee will be responsible for advising and directing the student through the PhD program.

Year 3

The General Examination. By the end of the third year, the student will take the General Examination.  This examination is in the format of a written research grant proposal that is presented to the PhD supervisory committee. All required coursework must be completed at this time.  The purposes of this examination are (1) to determine whether the student is capable of recognizing an important research question in oral and craniofacial sciences, (2) to determine whether the student is able to develop this question into a comprehensive proposal complete with preliminary findings and suggested methods of procedure, and to orally defend the proposal, and (3) to provide the student an opportunity to receive feedback from the Supervisory Committee on the proposed research project.

Year 3 to Completion

The student will primarily engage in thesis research and additional advanced coursework.

The Dissertation and the Dissertation Examination. When the candidate has completed the research project, written the dissertation, and had it approved by the reading committee, the mentor will obtain approval from the Graduate School and set a date for the Final Examination.  The Final Examination will be concerned principally with the subject matter of the dissertation and is conducted as an open seminar followed by examination by the Supervisory Committee.

The research project for the PhD dissertation will be chosen by the candidate and adviser and be approved by the candidate’s Supervisory Committee.  The research must represent a worthy and fundamental contribution showing originality in concept and implementation.

Courses

A. Core Courses. The following courses are mandatory program requirements.
Course No. Course Title Credits Hrs. Quarter
Offered
DPHS 568 Biostatistics 3 S
PERIO 575 Oral Immunology 2 A
ORALB 569 Advanced Oral Microbiology
(Offered every other year, even years)
2 W, even years
ORALB 575 Oral Biology Seminars 1 A, W, Sp
ORALB 578 Research Techniques in Oral Biology
(lab rotations- minimum of 2 required)
2-4 A, W, Sp, S
ORALB 579 Molecular Biology 2 S
ORALB 580 Introduction to Molecular Biology Laboratory
(Offered every other year, even years)
4 A, even years
ORALB 581 Secretory Process in Exocrine Glands 2 variable
ORALB 591 Advanced Topics in Oral Biology/Medicine
(Craniofacial & Dental Development)
2 W
ORALB 600 Independent Study/Research var A, W, Sp, S,
ORALB 800 Doctoral Dissertation
(a minimum of 27 credits needed)
var A, W, Sp, S

Students must also take at least 6 credits from the School of Medicine (CONJ 524-551, typically 1.5 credits each) or Bioinformatics (PABIO 536, 3 credits).  Because these courses are from outside Oral Biology, they (and Biostatistics, DPHS 568, 3 credits, & PERIO 575, 2 credits listed above) can be applied to the out-of-department requirement of 15 credits.  The additional 6 required credits in science courses from outside Oral Biology can be selected from any appropriate program.  See the list of recommended electives below for suggestions.

B. Following is a list of the conjoint/pabio offerings:
Course No. Course Title Credit Hrs. Quarter
Offered
CONJ 504 Molecular Medicine 1.5 Sp
CONJ 514 Molecular Medicine 3 W
CONJ 524 Structural Basis of Signal Transduction 1.5 W
CONJ 526 Systems Biology 1.5 W
CONJ 530 Directing Stem Cells Toward Regenerative Med 1.5 Sp/A
CONJ 531 Signaling Mechanisms in Excitable Cells 1.5 A
CONJ 532 Signal Transduction 1.5 A
CONJ 533 Dynamic Chromosome 1.5 A
CONJ 534 Problems in Nervous System Development 1.5 W
CONJ 535 RNA Structure & Biological Function 1.5 W
CONJ 537 Mechanism of Transcriptional Regulations 1.5 A
CONJ 539 Biological Basis of Neoplasia 1.5 Sp
CONJ 541 Molecular Biology of Cellular Processes 1.5 Sp
CONJ 542 Development 1.5 W
CONJ 544 Protein Structure, Modification and Regulation 1.5 W
CONJ 545 Molecular Interactions and Medicine 1.5 Sp
CONJ 546 Survey of Technologies for Molecular Biology 1.5 A
CONJ 548 Modeling Proteins and Proteomes 1.5 W
CONJ 549 Microbial Population Biology 1.5 W
CONJ 550 Clinical Infectious Diseases 3 W
CONJ 551 Immunity 1.5 Sp
CONJ 552 Metabolic Flexibility in Biology 1.5 A
CONJ 557 Microbial Evolution 1.5 Sp
CONJ 558 Prokaryotic Biology 1.5 W
CONJ 559 Scientific Ideas at Work 1.5 Sp
CONJ 583 Targets in Cancer 1.5 A
PABIO 536 Bioinformatics and Gene Sequence Analysis 3 Sp
C. Recommendations for prerequisites. Some students may need to take some lower level division courses in order to prepare for required classes. See the following list for suggestions:
Course No. Course Title Credit Hrs. Quarter
Offered
BIOC 405 Introduction to Biochemistry 3 A
BIOC 406 Introduction to Biochemistry 3 W
BIOL 411 Developmental Biology 4 A, W
MICROM 411 Gene Action 5 W
IMMUN/MICRO 441 Introduction to Immunology 4 A

D. Other electives Students are expected to take additional courses in bioengineering, epidemiology, immunology, or other basic biological/medical sciences as appropriate for their research interests. At least 6 such credits are required. The student will work with the Graduate Program Coordinator and their mentor (if chosen) to select appropriate elective courses in their chosen basic biological science pathway. The list below is not meant to be exhaustive.

Other Electives
Course No. Course Title Credit Hrs. Quarter
Offered
BIOC 530 Introduction to Structural Biology 3 A
BIOEN 501 Molecular Bioengineering 4 A
BIOEN 502 Cellular Bioengineering 4 A
DPHS 569 Clinical Epidemiology 2 S
GENOME 551 Gene Regulation 1.5 A
GENOME 552 Genomics 1.5 A
GENOME 553 Genetic Analysis 1.5 W
IMMUN 532 Advanced Immunology 4 W
MCB 532 Human Pathogenic Viruses 3 A
MCB 521 Embryos, Genes, and Development 4 W
MICROM/IMMUN 441 Intro to Immunology 4 A
MICROM 445 Medical Virology 2 Sp
MICROM 553 Molecular Mechanisms of Bacterial Pathogenesis 3 A, even years
NBIO 401 Systems Neurobiology 3 A
NBIO 402 Neuropathophysiology 3 W
NBIO 403 Systems and Behavioral Neurobiology 3 W
NBIO 404 Neuropharmacology 3 Sp
PABIO 551 Biochemistry & Genetics of Proteins & Hosts 4 A
PABIO 552 Cell Biology of Human Pathogens & Disease 4 W
PABIO 553 Diseases of Public Health Importance & Strategies for their Control 4 Sp
PABIO 568 Molecular Epidemiology of Infectious Diseases 2 W
ORTHO 580 Craniofacial Anatomy 3 Sp
E. Other Oral Biology Electives:
Course No. Course Title Credit Hrs. Quarter
Offered
ORALB 564, 565
(Yr 1 = 564; Yr 2 = 565)
Clinical & Histopathological Correlation 2 A, W, Sp, S
ORALB 574 Clinical Stomatology 3 Sp

F. In order to prepare for teaching, it is strongly recommended that the student take at least one class on educational methods. Such credits will not fulfill the requirement for out-of-department science courses, but will count toward the total credits required.

Suggested courses include, but are not limited to:
Course No. Course Title Credit Hrs. Quarter
Offered
MEBI 520 Teaching Methods in Medical Education 2 varies
MEBI 521 Evaluation of Learning in the Health Sciences 3 Sp
ORALB 562 Supervised Teaching in Oral Biology Var. A, W, Sp, S

G. Students are also required to attend and participate in the Biomedical Research Integrity Series. This is a non-credit summer course taught through the Department of Medical History & Ethics and consists of a series of lectures and discussion groups. Each student will need to attend a minimum of three lectures and three discussion groups.

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