Seminars in Dental and Craniofacial Clinical Research Methods

Fundamentals of Randomized Clinical Trials and Observational Studies

Time: 2:00–4:00 MW • Faculty: McKinney, DeRouen, Cunha-Cruz

Fundamentals of designing randomized clinical trials and observational studies will be discussed. Topics on observational studies will include the fundamentals of designing cross-sectional, case control, cohort, and community-based participatory studies. Topics on randomized clinical trials to be addressed include: what constitutes a clinical trial; reasons why clinical trials are used; characteristics of good trials; ethical issues; and special topics in clinical trials including recruitment, compliance, and limitations of results.

Seminar on Grantsmanship

Time: 2:00–4:00 MW • Faculty: McKinney

Introduction to the grant review process; types of grants; criteria used in evaluating grants; elements of strong grant applications; human subjects and other ethical issues. Participants are divided into teams and go through the process of developing an interdisciplinary grant proposal, which integrates their learning and serves as a capstone project.


Time: 8:00–9:30 MWF • Faculty: Leroux

This is provides an introduction to biostatistics. Topics covered include descriptive statistics, elementary probability, comparison of two-sample means and proportions, simple linear regression and correlation. Parametric and non-parametric methods are discussed. More advanced methods (multiple regression, analysis of variance, logistic regression) are briefly described but not covered in detail. Applications and examples in dentistry are stressed throughout.

Behavior and Measurement in Dental Research

Time: 10:00–11:30 MWF • Faculty: Heaton, Coldwell, Coolidge, Cunha-Cruz, Grembowski, McKinney, Mancl, Ramsay, Seminario, Dickstein

This seminar series is designed to introduce some of the most commonly used methods in behavioral dental research and common challenges in measurement in dental research studies. Applications to studies of dental fear, pain, autism in dentistry, neurosensory assessment, dental services utilization, outcomes of major dental procedures, orthodontic treatment, and pediatric and global oral health are included.


Clinical Epidemiology & Study Design in Dentistry

Time: 8:00–9:30 TTh • Faculty: Hujoel

This seminar provides an overview of applied scientific principles in clinical research. Topics covered include biological plausibility, the importance of comparison and temporality in establishing causality, data torturing, the formulation of a research question, refutation, placebo effects, and scientific conflicts of interest. Application and real life examples of issues in three specific research designs are covered: the case-control design, the cohort design, and the randomized controlled trial.

Computing Applications & Data Analysis

Time: 10:00–12:00 TTh • Faculty: Leroux

Participants will learn how to use a variety of computer software packages for research applications. Applications include web resources, PowerPoint and table presentations, data analysis using Excel and SPSS, REDCap and sample size calculations using PS software. This hands-on seminar analyzes data sets from oral health studies and is designed to reinforce principles covered in other seminars (e.g. Biostatistics).

Molecular Biology & Oral Health Applications (elective)

Time: 1:30–2:20 TTh, Room RR-134, Health Sciences Building • Faculty: Presland, Roberts

This seminar is designed as an introduction to molecular biology and recombinant DNA techniques, and its applications. It will discuss both basic concepts of molecular biology such as nucleic acid structure and function, RNA and protein synthesis, and applications that are relevant to oral health and dentistry as well as biological sciences in general. The participant is provided a broad understanding of molecular biology and genetics, and how these disciplines are revolutionizing all aspects of biology and health care.

Craniofacial Research Seminar (elective)

Time: 3:00 – 5:00 pm Th •  Faculty: McKinney, Guest Lecturers

This seminar series presents a framework and overview of the translational spectrum of craniofacial research from basic science and clinical research to product development. It showcases a broad range of study designs and topics using dental and craniofacial projects conducted by University of Washington and Seattle Children’s Hospital Craniofacial Center faculty as case studies.