Jeffrey Vieira, PhD
Adjunct Research Associate Professor, Oral Health Sciences
Research Associate Professor, Laboratory Medicine
The laboratory primarily works on the molecular biology of Kaposi’s sarcoma-associated herpesvirus (KSHV), the eighth human herpesvirus (HHV-8). KSHV is involved in Kaposi’s sarcoma, primary infusion lymphoma, and some forms of multicentric Castleman’s disease. All herpesviruses can alternate between latent and lytic replication, which allows the permanent infection of the host, and is a vital aspect of the pathogenesis of these viruses. One area of research for the lab is the understanding of viral and cellular factors important for the activation of lytic genes, and the activation of lytic replication during the development of epithelium. We employ a recombinant KSHV that allow the distinction between latent and lytic gene expression by the expression of different fluorescent proteins. The lab also works on KSHV gene functioning and immunology.
- Johnson, A.S., Maronian N., Vieira J. (Nov 2005) Activation of Kaposi’s sarcoma-associated herpesvirus lytic gene expression during epithelial differentiation. Journal of Virology, 79(21) 13769-77.
- Vieira J., O’Hearn P.M. (Aug 2004). Use of the red fluorescent protein as a marker of Kaposi’s sarcoma-associated herpesvirus lytic gene expression. Virology, 325(2)225-40.
- Kimball L.E., Casper C., Koelle D.M., Morrow R., Corey L, Vieira, J (June 2004) Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma. The Journal of Infectious Diseases, 189(11)2016-22.