Dr. Somerman

Dr. Somerman

Martha Somerman, DDS, PhD

Email: somerman@uw.edu


Affiliate Professor, Periodontics

Interests

Dr. Somerman’s laboratory, under funded NIDCR/NIH research grants, is focusing on projects directed at:

  1. understanding the mechanisms and factors regulating the development, maintenance and regeneration of periodontal structures and
  2. determining the appropriate cells, genes (factors), and scaffolds required for re-engineering periodontal structures lost as a consequence of disease.

The laboratory also has industrial support with interests in understanding regulators of osteoclast-osteoblast function in healthy and diseased periodontium.

Publications

  1. Osathanon T, Linnes ML, Rajachar RM, Ratner BD, Somerman MJ, Giachelli CM. Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials 29 4091-4099, 2008.
  2. Sato S, Kitagawa M, Sakamoto K, Iizuka S, Kudo Y, Ogawa I, Miyauchi M, Chu EY, Foster BL, Somerman MJ, Takata T. Enamel matrix derivative exhibits anti-inflammation properties in monocytes. J Periodontol 79(3) 535-540, 2008.
  3. Noguchi K, Miyauchi M, Oka H, Komaki M, Somerman MJ, Takata T. Cyclooxygenase-2-dependent prostaglandin E(2) upregulates interleukin (IL)-1alpha-induced IL-6 generation in mouse cementoblasts. J Periodontol. 2007 Jan; 78(1):135-40.
  4. Zhang H, Somerman MJ, Berg J, Cunningham ML, Williams B. Dental anomalies in a child with craniometaphysial dysplasia. Pediatr Dent. 2007 Sep-Oct; 29(5):415-9.
  5. Oka H, Miyauchi M, Sakamoto K, Moriwaki S, Niida S, Noguchi K, Somerman MJ, Takata T. PGE2 activates cementoclastogenesis by cementoblasts via EP4. J Dent Res. 2007 Oct; 86(10):974-9.
  6. Darveau RP, Foster BL, Nogueira-Filho GR, Somerman MJ. Regulation of cementoblast function by P. gingivalis lipopolysaccharide via TLR2. Journal of Dental Research 85(8): 733-738, 2006.
  7. Berry JE, Ealba EL, Pettway GJ, Datta NS, Swanson EC, Somerman MJ, McCauley LK. JunB as a downstream mediator of PTHrP actions in cementoblasts. Journal of Bone and Mineral Research 21(2):246-257, 2006.
  8. Hakki SS, Wang D, Franceschi RT, Somerman MJ. Bone Sialoprotein Gene Transfer to Periodontal Ligament Cells May Not Be Sufficient to Promote Mineralization In Vitro or In Vivo. J Periodontol, 77:167-173, 2006.
  9. Foster BL, Nociti FH, Swanson EC, Matsa-Dunn D, Berry JE, Cupp CJ, Zhang P, Somerman MJ. Regulation of Cementoblast Gene Expression by Inorganic Phosphate, In Vitro. Calcif Tissue Int. 78:103-112, 2006.
  10. Rutherford R, Foster BL, Bammler T, Beyer D, Sato S, Somerman MJ. Extracellular Phosphate Alters Cementoblast Gene Expression. Journal of Dental Research 85(6):505-509, 2006.
  11. Woo KM, Jun JH, Chen VJ, Seo J, Baek JH, Ryoo HM, Kim GS, Somerman MJ, Ma PX. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 2006 Jul 17.

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