Nancy Kiviat, MD
HMC 325 9th Ave
Adjunct Professor, Oral Health Sciences
Nancy Kiviat, MD is Professor of Pathology at the University of Washington and Director of the Cytopathology Service and Molecular Diagnostics Laboratory at Harborview Medical Center. Dr. Kiviat is also an Adjunct Professor in the Department of Medicine at the University of Washington, and a Full Member in the Program of Cancer Biology at the Fred Hutchinson Cancer Research Center, Seattle, Washington. Dr. Kiviat has participated on several national committees including the National Committee for establishment of criteria of the Bethesda Cytologic Classification System, and several NIH Standing Study sections for Epidemiology, and AIDS and related research. Dr. Kiviat’s research focuses on studies of HIV-1, HIV-2, and HPV-related cancers, as well as breast cancer, especially in Africa.
She directs projects examining issues related to cervical cancer control both in developing countries and in the U.S., as well as studies exploring management of women with abnormal Pap smears in the U.S. Over the last several years Dr. Kiviat has been involved in several projects examining the development of biomarkers for detection of cervical, heart, and ovarian cancer. Currently there are ongoing NIH-funded projects in her research labs in Seattle and Senegal, West Africa. Dr. Kiviat is currently also interested in the role of HPV infection in head and neck cancer. It has been known that a subset of head and neck cancer, especially oropharyngeal cancer, is caused by HPV 16 infection. HPV 16 positive oropharyngeal cancer is more aggressive, though more likely to be responsive to chemotherapy. Recent epidemiology studies indicates that by 2020, the incidence of oropharyngeal cancer will surpass the incidence of cervical cancer in the US. Her current projects in head and neck cancer involves characterization of genital HPV infection in oral cavity cancer from both HIV+ and HIV- women, identification of novel oral HPV in tumorigenesis, and efficacy of prophylactic HPV vaccine in prevention of oral cancer.
1. Xi, L.F.; Hughes, J.P.; Castle, P.E.; Edelstein, Z.R.; Wang, C.; Galloway, D.A.; Koutsky, L.A.; Kiviat, N.B.; Schiffman, M. Viral Load in the Natural History of Human Papillomavirus Type 16 Infection: A Nested Case-control Study. The Journal of infectious diseases. 2011; 203(10):1425-1433.
2. Xi, L.F.; Hughes, J.P.; Edelstein, Z.R.; Kiviat, N.B.; Koutsky, L.A.; Mao, C.; Ho, J.; Schiffman, M. Human Papillomavirus (HPV) type 16 and type 18 DNA Loads at Baseline and Persistence of Type-Specific Infection during a 2-year follow-up. J Infect Dis. 2009; 200(11):1789-1797.
3. Sabath, A.P.; Kiviat, N.B. Detection and classification of cervical neoplasia in the era of HPV. Pathology Case Reviews. 2010; 15(4):135-140.
4. Winer, R.L.; Hughes, J.P.; Feng, Q.; Xi, L.F.; Cherne, S.L.; Oreilly, S.; Kiviat, N.B.; Koutsky, L.A. Early Natural History of Incident Type-Specific Human Papillomavirus Infections in Newly Sexually Active Young Women. Cancer Epidemiol Biomarkers Prev. 2010.
5. Hanisch, R.A.; Sow, P.S.; Feng, Q.; Gottlieb, G.; Kiviat, N.; Hawes, S.E., Influence of HIV type-specific infection and CD4 count on cervical HPV DNA detection in women from Senegal, West Africa, in 2011 International AIDS Society meeting. 2011: Rome, Italy.