Dr. Giachelli

Dr. Giachelli

Cecilia Giachelli, PhD

Office: N-330L, Foege
Box: 355061
Email: ceci@uw.edu

Adjunct Professor, Oral Health Sciences
Professor, Bioengineering

Interests

Current projects include:

  • Identifying and applying biomimetic strategies to cell-substrate interactions important for promoting endothelial survival and angiogenesis particularly in the context of biomaterial healing,
  • Biomolecular control of the foreign body reaction, with particular emphasis on the macrophage-mediated inflammatory response to biomaterials
  • Mechanistic studies aimed at developing novel therapeutic targets and approaches for preventing ectopic calcification in disease and medical devices
  • Cardiac valve and esophageal tissue engineering.

Publications

  1. Rajachar R, Truong A, Giachelli CM. The influence of surface mineral and osteopontin on the formation and function of murine bone marrow macrophage derived osteoclasts, J Biomed Mater Res, J Mater Sci Mat med, 2008.
  2. M. Linnes, B.D. Ratner, C.M. Giachelli. A Fibrinogen Based Precision Microporous Scaffold for Tissue Engineering: Development and Characterization. Biomaterials, 28(35):5298-306, 2007.
  3. Beckstead, B.L. and C.M. Giachelli. “Mimicking cell-cell interactions at the biomaterial-cell interface” J Biomed Mater Res A. 2006 Oct; 79(1):94-103.
  4. Li X, Ying-Yang H, Giachelli CM. Role of the Sodium Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Calcification. Circ Res. 2006 98:905-12, 2006.
  5. Tsai A, Rice J, Liaw L, Ratner B, Giachelli CM. Osteopntin reduces foreign body giant cell formation in response to biomaterial implantation. Biomaterials, 26:5835-43, 2005.
  6. Ohri R, Tung E, Rajachar R, Giachelli CM. Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin: efficacy, potency and mechanism. Calcified Tissue Intl, 76:307-15, 2005.
  7. Cuy JL, Beckstead BL, Brown CD, Hoffman AS, Giachelli CM. Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. J Biomed Mater Res, 67A: 538-547, 2003.
  8. Wiester LM, Giachelli CM. Expression and function of the integrin, a9b1, in bovine aortic valve interstitial cells. J Heart Valve Disease, 12: 605-616, 2003.
  9. Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E, Karsenty G, Giachelli CM. Inactivation of the osteopontin gene enhances vascular calcification of matrix gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 196: 1047-1055, 2002.
  10. Steitz SA, McKee MD, Liaw L, Giachelli CM. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Amer J Path 16:2035-2046, 2002.

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